“Whoa! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Get 2 Weeks Free

Effect of secretin on glomerular dynamics in dogs

Abstract These studies were performed to determine whether a role for increased renal plasma flow (RPF) in the regulation of glomerular filtration rate (GFR) could be demonstrated in dogs by infusing the polypeptide hormone secretin, a vasodilator that has been reported to increase GFR. Differences between control and recollection periods were compared by paired t test in five time-control dogs (group 1) and 10 secretin dogs (group 2). In group 2, secretin (100 mU . kg-1 . min-1, ia) significantly increased single-nephron glomerular filtration rate (SNGFR) 11.1 +/- 3.1 nl/min (20%) and glomerular plasma flow 59 +/- 11 nl/min (26%). Similar increases in GFR (26%) and RPF (29%) were observed. Secretin also increased glomerular capillary pressure 5.2 +/- 0.8 mmHg and free-flow proximal tubule pressure 5.5 +/- 1.0 mmHg. Secretin did not significantly affect average effective filtration pressure (EFP) but significantly increased the ultrafiltration coefficient (Kf) 0.74 +/- 0.14 nl . min-1 . mmHg-1. These differences were significantly greater than those observed in group 2. It is concluded that secretin increased SNGFR primarily by an effect on Kf. This is consistent with the marked effect that Kf is predicted to have on glomerular filtration in dogs. The maintenance of EFP agrees with other vasodilator studies and indicates that GFR is only moderately dependent on plasma flow in dogs. Copyright © 1986 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Renal Physiology The American Physiological Society

Loading next page...

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for just $40/month

Get 2 Weeks Free

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.