MEKINE~, AI-U J., BENTE BENTE TR~NIER, Am WENRIK SONNE, PETER A. FARRELL, GALBO.Effect ofphysicaZ exer- cise on sensitivity and responsiveness to insulin in humans. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E248-E259, 1988.The effect of physical exercise on insulin sensitivity and responsiveness of uptake and hepatic production was studied. Seven untrained men were subjected to four sequential euglycernic hyperinsulinemic clamps after rest (R), immediat.ely after exercise (E), as well as 48 h after 60 min of 1561)W ergometer exercise (ER). Insulin-mediat,ed uptake was higher on E and ER days compared with R days. Apparent K,, decreased after exercise (52 & 3 R vs. 43 + 4 E and 40 -t- 3 ER pI.J/ml, means rt SE) and Vmax increased (9.5 t 02 R vs. 10.9 _P 0.7 E and 10.7 t- 0.8 ER mg* min-â *kg-l). oxidation increased with the increasing insulin infusion rate, and maximal oxidation rate was lower on E days compared with R days, The maximal conversion rate of to glycogen was higher on E and ER days (8.0 _t 0.3 and 7.2 k 0.2, respectively) than on R days (5.7 & 0.6 mga mm1 . kg--l). Mucls e glycogen synthase I activity was higher
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Mar 1, 1988
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