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Research, CRANDALL,DAVID L., FONG M. LAI,FLORENCE J. HUGGINS, TARAK K. TANIKELLA, AND PETER CERVONI. Effect ofcaZoric restriction on cardiac reactivity and P-adrenoceptor concentration. Am. J. Physiol. 244 (Heart Circ. Physiol. 13): H444H448, 1983.-The effect of a 21-day program of caloric restriction on cardiac reactivity and P-adrenoceptor number was investigated in male Sprague-Dawley rats. Rats on the restricted diet (Restricted) exhibited significant decreases in body weight, epididymal fat pad, and retroperitoneal fat pad weight as well as the percent of body fat represented by these adipose tissue depots when compared with rats fed ad libitum (Fed). Fed rats exhibited significantly increased total heart weight and total heart protein, but the percent cardiac protein and ratio of heart weight to body weight were similar in Fed and Restricted rats. Isolated atria from Fed and Restricted rats developed similar chronotropic and inotropic responses over a range of isoproterenol concentrations. Although total P-adrenoceptor number (fmol/heart) was greater in Fed rats, the concentration of P-adrenoceptors (fmol/mg protein) was remarkably similar regardless of the dietary regimen. Therefore, despite significant decreases in body weight, body fat, and heart weight, the myocardium of Restricted rats maintained the capability of responding to isoproterenol as that of Fed
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Mar 1, 1983
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