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Effect of caloric restriction on cardiac reactivity and beta-adrenoceptor concentration

Effect of caloric restriction on cardiac reactivity and beta-adrenoceptor concentration Research, CRANDALL,DAVID L., FONG M. LAI,FLORENCE J. HUGGINS, TARAK K. TANIKELLA, AND PETER CERVONI. Effect ofcaZoric restriction on cardiac reactivity and P-adrenoceptor concentration. Am. J. Physiol. 244 (Heart Circ. Physiol. 13): H444H448, 1983.-The effect of a 21-day program of caloric restriction on cardiac reactivity and P-adrenoceptor number was investigated in male Sprague-Dawley rats. Rats on the restricted diet (Restricted) exhibited significant decreases in body weight, epididymal fat pad, and retroperitoneal fat pad weight as well as the percent of body fat represented by these adipose tissue depots when compared with rats fed ad libitum (Fed). Fed rats exhibited significantly increased total heart weight and total heart protein, but the percent cardiac protein and ratio of heart weight to body weight were similar in Fed and Restricted rats. Isolated atria from Fed and Restricted rats developed similar chronotropic and inotropic responses over a range of isoproterenol concentrations. Although total P-adrenoceptor number (fmol/heart) was greater in Fed rats, the concentration of P-adrenoceptors (fmol/mg protein) was remarkably similar regardless of the dietary regimen. Therefore, despite significant decreases in body weight, body fat, and heart weight, the myocardium of Restricted rats maintained the capability of responding to isoproterenol as that of Fed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Effect of caloric restriction on cardiac reactivity and beta-adrenoceptor concentration

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Publisher
The American Physiological Society
Copyright
Copyright © 1983 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

Research, CRANDALL,DAVID L., FONG M. LAI,FLORENCE J. HUGGINS, TARAK K. TANIKELLA, AND PETER CERVONI. Effect ofcaZoric restriction on cardiac reactivity and P-adrenoceptor concentration. Am. J. Physiol. 244 (Heart Circ. Physiol. 13): H444H448, 1983.-The effect of a 21-day program of caloric restriction on cardiac reactivity and P-adrenoceptor number was investigated in male Sprague-Dawley rats. Rats on the restricted diet (Restricted) exhibited significant decreases in body weight, epididymal fat pad, and retroperitoneal fat pad weight as well as the percent of body fat represented by these adipose tissue depots when compared with rats fed ad libitum (Fed). Fed rats exhibited significantly increased total heart weight and total heart protein, but the percent cardiac protein and ratio of heart weight to body weight were similar in Fed and Restricted rats. Isolated atria from Fed and Restricted rats developed similar chronotropic and inotropic responses over a range of isoproterenol concentrations. Although total P-adrenoceptor number (fmol/heart) was greater in Fed rats, the concentration of P-adrenoceptors (fmol/mg protein) was remarkably similar regardless of the dietary regimen. Therefore, despite significant decreases in body weight, body fat, and heart weight, the myocardium of Restricted rats maintained the capability of responding to isoproterenol as that of Fed

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Mar 1, 1983

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