Effect of anesthetic on sympathetic responses evoked from cerebellar uvula in decerebrate cats

Effect of anesthetic on sympathetic responses evoked from cerebellar uvula in decerebrate cats 0363-6135/92 $2.00 Copyright showing a convergence of auditory, nociceptive, proprioceptive, visual, and vestibular afferents to the uvula (3). The present experiments were performed to examine the effect of anesthesia on the uvula- tachycardia-pressor response observed in the decerebrate animal. We previously reported that the sympathoexcitatory response was qualitatively reversed by administration of anesthetic agents to the decerebrate preparation (6, 7, 17,20). Indeed, in either the intact anesthetized or anesthetized decerebrate animal, both electrical and glutamate activation of the uvula a sympathoinhibitory response consisting of decreases in heart rate and arterial blood pressure together with a cessation of ongoing discharge in nerves innervating the kidney, vasodilatation in the femoral vascular bed, and central apnea (6, 7, 17, 20). This visceral pattern of response is analogous to that seen during a “play dead” type response in the conscious rabbit, which was accompanied by a cessation of ongoing motor activity (1) and also during electrical stimulation of the central nucleus of the amygdala in the anesthetized rabbit (8). Thus the present study was designed to investigate the underlying mechanisms responsible for the reversal in the cardiovascular pattern of response the uvula in the unanesthetized and anesthetized decerebrate animal. The results of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Effect of anesthetic on sympathetic responses evoked from cerebellar uvula in decerebrate cats

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Publisher
The American Physiological Society
Copyright
Copyright © 1992 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
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Abstract

0363-6135/92 $2.00 Copyright showing a convergence of auditory, nociceptive, proprioceptive, visual, and vestibular afferents to the uvula (3). The present experiments were performed to examine the effect of anesthesia on the uvula- tachycardia-pressor response observed in the decerebrate animal. We previously reported that the sympathoexcitatory response was qualitatively reversed by administration of anesthetic agents to the decerebrate preparation (6, 7, 17,20). Indeed, in either the intact anesthetized or anesthetized decerebrate animal, both electrical and glutamate activation of the uvula a sympathoinhibitory response consisting of decreases in heart rate and arterial blood pressure together with a cessation of ongoing discharge in nerves innervating the kidney, vasodilatation in the femoral vascular bed, and central apnea (6, 7, 17, 20). This visceral pattern of response is analogous to that seen during a “play dead” type response in the conscious rabbit, which was accompanied by a cessation of ongoing motor activity (1) and also during electrical stimulation of the central nucleus of the amygdala in the anesthetized rabbit (8). Thus the present study was designed to investigate the underlying mechanisms responsible for the reversal in the cardiovascular pattern of response the uvula in the unanesthetized and anesthetized decerebrate animal. The results of

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Oct 1, 1992

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