YAIR SHAPIRO, ILAN of an acute bout of glucose disposal human . J. Appl. Physiol. 69(l): 299-304, 1990.-The of acute sul acti has been studied six obese (150-250% ideal body weight) n-sul-dependent diabetics (OD), seven obese normoglycemics (), and six lean healthy ctrols (LC). Usg a three-stage euglycemic clamp, the metabolic clearance rate (MCR) of glucose under creasg sul ccentratis was measured. The sul dose-respse curve was assessed two separate occasis: 1) a base-le test and 2) 1 h after aerobic treadmill at a steady-state heart rate of 150160 beats/m. the base-le test, under all sul levels, glucose MCR was significantly lower obese compared with lean dividuals (P c 0.01). creased glucose MCR at the highest hormal ccentratis applied to 124 and 134% of base le OD and , respectively (P < 0.05); the sul ccentrati required for e-half of the maximal clearance rate of glucose achieved this study decreased from 200 to 130 and from 160 to 95 ,uU/ml OD and , respectively (P C 0.05). The changes these parameters were significant LC. It is suggested that acute affected the sul dose-respse curve OD and but not LC; although enhanced by , glucose MCR remaed significantly lower
Journal of Applied Physiology – The American Physiological Society
Published: Jul 1, 1990
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