Dual adrenergic control of renin during nonhypotensive hemorrhage in conscious dogs

Dual adrenergic control of renin during nonhypotensive hemorrhage in conscious dogs M. GENGO. Dual norepinephrine; epinephrine; arginine vasopressin; aldosterone; blood volume; blood pressure; cw- receptors; ,& receptors; phenoxybenzamine; propranolol MEAN ARTERIAL PRESSURE is stable slow blood withdrawal up to -20% total blood volume in conscious dogs (20,22, 24). The compensatory responses to slow include increased sympathetic nervous system activity (20)) increased vasopressin release (22, 24), and increased plasma activity (PRA) (22, 24). Renal nerve activity is elevated nonhypotensive (20), and the accompanying increase in PRA may therefore reflect stimulation release by the renal sympathetic nerves. Adrenomedullary catecholamine release is also augmented (8), and the resulting increase in plasma catecholamine concentration may additionally contribute to stimulation E910 0193-1849/91 $1.50 Copyright release. Thus nonhypotensive provides a condition in which the mechanism(s) by which reflex increases in sympathetic nervous system activity increase PRA can be evaluated. It has been extensively documented that renal ,&adrenoceptors are stimulatory to release and mediate increased secretion rate when the renal nerves are electrically stimulated (6, 17). In addition to renal ,& adrenoceptors, however, at least two other mechanisms may contribute to increased release when sympathetic nervous system activity is elevated. Renal cu-adrenoceptors also mediate part the increase in release that occurs electrical stimulation the renal sympathetic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Dual adrenergic control of renin during nonhypotensive hemorrhage in conscious dogs

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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
See Article on Publisher Site

Abstract

M. GENGO. Dual norepinephrine; epinephrine; arginine vasopressin; aldosterone; blood volume; blood pressure; cw- receptors; ,& receptors; phenoxybenzamine; propranolol MEAN ARTERIAL PRESSURE is stable slow blood withdrawal up to -20% total blood volume in conscious dogs (20,22, 24). The compensatory responses to slow include increased sympathetic nervous system activity (20)) increased vasopressin release (22, 24), and increased plasma activity (PRA) (22, 24). Renal nerve activity is elevated nonhypotensive (20), and the accompanying increase in PRA may therefore reflect stimulation release by the renal sympathetic nerves. Adrenomedullary catecholamine release is also augmented (8), and the resulting increase in plasma catecholamine concentration may additionally contribute to stimulation E910 0193-1849/91 $1.50 Copyright release. Thus nonhypotensive provides a condition in which the mechanism(s) by which reflex increases in sympathetic nervous system activity increase PRA can be evaluated. It has been extensively documented that renal ,&adrenoceptors are stimulatory to release and mediate increased secretion rate when the renal nerves are electrically stimulated (6, 17). In addition to renal ,& adrenoceptors, however, at least two other mechanisms may contribute to increased release when sympathetic nervous system activity is elevated. Renal cu-adrenoceptors also mediate part the increase in release that occurs electrical stimulation the renal sympathetic

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Jun 1, 1991

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