ALAN R. SALTIEL Department of Signal Transduction, Parke-Davis Warner-Lambert, Ann Arbor, Michigan 48105 Pharmaceutical Research, Saltiel, Alan R. Diverse signaling pathways in the cellular actions of insulin. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E375-E385,1996.Insulin is one of the most important regulators of glucose and lipid homeostasis. Many of its cellular actions are mediated by changes in protein phosphorylation. The consequences of these phosphorylation events extend from a series of different short-term metabolic actions to longer-term effects of the hormone on cellular growth and differentiation. Although the insulin receptor itself is a tyrosine kinase that is activated upon hormone binding, the ensuing changes in phosphorylation occur predominantly on serine and threonine residues. Moreover, insulin can simultaneously stimulate the phosphorylation of some proteins and the dephosphorylation of others. These paradoxical effects of insulin suggest that separate signal transduction pathways may emanate from the receptor itself to produce the pleiotropic actions of the hormone. protein phosphorylation; src homology domain intermediary metabolism; protein phosphatase; the chemistry and physiology of insulin since its discovery 75 years ago. Insulin is among the most potent of anabolic agents, promoting the synthesis and storage of carbohydrates, lipids, and proteins and inhibiting their degradation and release
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Mar 1, 1996
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