Diverse signaling pathways in the cellular actions of insulin

Diverse signaling pathways in the cellular actions of insulin ALAN R. SALTIEL Department of Signal Transduction, Parke-Davis Warner-Lambert, Ann Arbor, Michigan 48105 Pharmaceutical Research, Saltiel, Alan R. Diverse signaling pathways in the cellular actions of insulin. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E375-E385,1996.Insulin is one of the most important regulators of glucose and lipid homeostasis. Many of its cellular actions are mediated by changes in protein phosphorylation. The consequences of these phosphorylation events extend from a series of different short-term metabolic actions to longer-term effects of the hormone on cellular growth and differentiation. Although the insulin receptor itself is a tyrosine kinase that is activated upon hormone binding, the ensuing changes in phosphorylation occur predominantly on serine and threonine residues. Moreover, insulin can simultaneously stimulate the phosphorylation of some proteins and the dephosphorylation of others. These paradoxical effects of insulin suggest that separate signal transduction pathways may emanate from the receptor itself to produce the pleiotropic actions of the hormone. protein phosphorylation; src homology domain intermediary metabolism; protein phosphatase; the chemistry and physiology of insulin since its discovery 75 years ago. Insulin is among the most potent of anabolic agents, promoting the synthesis and storage of carbohydrates, lipids, and proteins and inhibiting their degradation and release http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Diverse signaling pathways in the cellular actions of insulin

Loading next page...
 
/lp/the-american-physiological-society/diverse-signaling-pathways-in-the-cellular-actions-of-insulin-0Tapuewj5c
Publisher site
See Article on Publisher Site

Abstract

ALAN R. SALTIEL Department of Signal Transduction, Parke-Davis Warner-Lambert, Ann Arbor, Michigan 48105 Pharmaceutical Research, Saltiel, Alan R. Diverse signaling pathways in the cellular actions of insulin. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E375-E385,1996.Insulin is one of the most important regulators of glucose and lipid homeostasis. Many of its cellular actions are mediated by changes in protein phosphorylation. The consequences of these phosphorylation events extend from a series of different short-term metabolic actions to longer-term effects of the hormone on cellular growth and differentiation. Although the insulin receptor itself is a tyrosine kinase that is activated upon hormone binding, the ensuing changes in phosphorylation occur predominantly on serine and threonine residues. Moreover, insulin can simultaneously stimulate the phosphorylation of some proteins and the dephosphorylation of others. These paradoxical effects of insulin suggest that separate signal transduction pathways may emanate from the receptor itself to produce the pleiotropic actions of the hormone. protein phosphorylation; src homology domain intermediary metabolism; protein phosphatase; the chemistry and physiology of insulin since its discovery 75 years ago. Insulin is among the most potent of anabolic agents, promoting the synthesis and storage of carbohydrates, lipids, and proteins and inhibiting their degradation and release

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Mar 1, 1996

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off