Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Distribution of cyclooxygenase products with cyclooxygenase inhibition in isolated dog lung

Distribution of cyclooxygenase products with cyclooxygenase inhibition in isolated dog lung THE ISOLATED LIJNG has many cell types, and synthesis of cyclooxygenase products from arachidonic acid may occur in these cells. Events such as vasodilation and vasoconstriction also may occur in isolated lungs. Studies have examined the possibility that synthesis of cyclooxygenase products contributes to such events (1, 5, 7, 11, 12, 16, 19-22). Inhibitors of synthesis of cyclooxygenase products have been used in such studies. This use is based, in part, on either the demonstration or the assumption that synthesis has been prevented in lung cells which are hypothesized to contribute to the event (e.g., vasodilation) being studied. of synthesis of cyclooxygenase products has been studied previously in isolated lungs in which the circulation was perfused with a salt solution. Cyclooxygenase inhibitors were added to the circulating 988 CYCLQOXYGENASE roller pump (Sarns 3500); a heat exchanger; a bubble trap with a column of perfusate topped by air and a latex seal, which also dampens arterial pressure swings; and an open venous reservoir. Residual blood was flushed from the circulation, and perfusion was initiated with a dextran-salt solution as perfusate. The white blood cell count of the circulating perfusate was <200/mm3, and the platelet count was <1,000/mm3. A zone http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Distribution of cyclooxygenase products with cyclooxygenase inhibition in isolated dog lung

Download PDF
6 pages

Loading next page...
 
/lp/the-american-physiological-society/distribution-of-cyclooxygenase-products-with-cyclooxygenase-inhibition-NqVOEmZsSc

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 1986 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
See Article on Publisher Site

Abstract

THE ISOLATED LIJNG has many cell types, and synthesis of cyclooxygenase products from arachidonic acid may occur in these cells. Events such as vasodilation and vasoconstriction also may occur in isolated lungs. Studies have examined the possibility that synthesis of cyclooxygenase products contributes to such events (1, 5, 7, 11, 12, 16, 19-22). Inhibitors of synthesis of cyclooxygenase products have been used in such studies. This use is based, in part, on either the demonstration or the assumption that synthesis has been prevented in lung cells which are hypothesized to contribute to the event (e.g., vasodilation) being studied. of synthesis of cyclooxygenase products has been studied previously in isolated lungs in which the circulation was perfused with a salt solution. Cyclooxygenase inhibitors were added to the circulating 988 CYCLQOXYGENASE roller pump (Sarns 3500); a heat exchanger; a bubble trap with a column of perfusate topped by air and a latex seal, which also dampens arterial pressure swings; and an open venous reservoir. Residual blood was flushed from the circulation, and perfusion was initiated with a dextran-salt solution as perfusate. The white blood cell count of the circulating perfusate was <200/mm3, and the platelet count was <1,000/mm3. A zone

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Sep 1, 1986

There are no references for this article.