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THE ISOLATED LIJNG has many cell types, and synthesis of cyclooxygenase products from arachidonic acid may occur in these cells. Events such as vasodilation and vasoconstriction also may occur in isolated lungs. Studies have examined the possibility that synthesis of cyclooxygenase products contributes to such events (1, 5, 7, 11, 12, 16, 19-22). Inhibitors of synthesis of cyclooxygenase products have been used in such studies. This use is based, in part, on either the demonstration or the assumption that synthesis has been prevented in lung cells which are hypothesized to contribute to the event (e.g., vasodilation) being studied. of synthesis of cyclooxygenase products has been studied previously in isolated lungs in which the circulation was perfused with a salt solution. Cyclooxygenase inhibitors were added to the circulating 988 CYCLQOXYGENASE roller pump (Sarns 3500); a heat exchanger; a bubble trap with a column of perfusate topped by air and a latex seal, which also dampens arterial pressure swings; and an open venous reservoir. Residual blood was flushed from the circulation, and perfusion was initiated with a dextran-salt solution as perfusate. The white blood cell count of the circulating perfusate was <200/mm3, and the platelet count was <1,000/mm3. A zone
Journal of Applied Physiology – The American Physiological Society
Published: Sep 1, 1986
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