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American Physiological Society Cl029 Matovcik, L. M., B. Haimowitz, J. R. Goldenring, A. J. Czernik, and F. S. Gorelick. Distribution of calcium/ calmodulin-dependent protein II in rat ileal enterocytes. Am. J. Physiol. 264 (Cell Physiol. 33): ClO29-C1036, 1993.Ca2+/calmodulin (CaM)-dependent protein II is a major effector of the Ca2+ signaling pathway. It has a wide tissue distribution and phosphorylates multiple substrates. Villus enterocytes from rat ileum contain a Ca2+/CaM-dependent activity that phosphorylates the exogenous neural substrate synapsin I. This phosphorylation is blocked by a specific peptide inhibitor. Antibodies made to rat brain Ca2+/CaMdependent protein II label a single band with a relative molecular mass of -50 kDa in isolated rat enterocytes by immunoblot. Almost one-half of this immunoreactive protein is preferentially found in a particulate compared with a soluble subcellular fraction of the enterocytes. Virtually all of the 50kDa band in the particulate fraction is insoluble in nonionic detergent, suggesting that the is associated with the enterocyte cytoskeleton. Antibodies to Ca2+/CaM-dependent protein II immunocytochemically detect fibrillar structures concentrated in the terminal web region of intestinal epithelial cells that colocalized with myosin II. This enzyme may have a role in regulating the intestinal epithelial cytoskeleton. multifunctional calmodulin-dependent protein ; enterocyte;
AJP - Cell Physiology – The American Physiological Society
Published: Apr 1, 1993
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