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Distinct cellular mechanisms of cholinergic and beta-adrenergic sweat secretion

Distinct cellular mechanisms of cholinergic and beta-adrenergic sweat secretion of California, Riverside, California neurohumoral GLS are under multiple control, but the physiological significance of such multiple regulatory control of exocrine funct is not understood (2,4,14, l&28). Secret from the human eccrine sweat gl is also under both choline& p-adrenergic control (4, 28, 29). The choline& P-adrenergic sweat secretory mechanisms appear to be different in at least two respects: 1) the P-adrenergitally induced secrets are relatively scanty compared with cholinergically induced secrets (4, 28, 29), 2) only the P-adrenergic, not cholinergic, secrets are affected in cystic fibrosis (CF) (29). We do not know the electrophysiological mechanisms employed by these two major physiological stimuli to explain the difference in fluid volume secret, nor do we underst why the genetic defect in CF has such a discriminating effect on P-adrenergically evoked exocrine secrets. The sweat gl secretory coil is one of the very few model systems in which different physiological mechanisms of secret from an electrophysiologically identified secretory cell can be examined (21,24). We (21,24) have recently shown that the sweat gl secretory coil is made up of three electrophysiologically distinct cell types: the contractile myoepithelial cells, which form an outer sheath around the inner two secretory cell EXOCRINE C486 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Distinct cellular mechanisms of cholinergic and beta-adrenergic sweat secretion

M. M. Reddy and C. L. Bell
AJP - Cell Physiology , Volume 271: C486 – Aug 1, 1996
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Publisher
The American Physiological Society
Copyright
Copyright © 1996 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
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Abstract

of California, Riverside, California neurohumoral GLS are under multiple control, but the physiological significance of such multiple regulatory control of exocrine funct is not understood (2,4,14, l&28). Secret from the human eccrine sweat gl is also under both choline& p-adrenergic control (4, 28, 29). The choline& P-adrenergic sweat secretory mechanisms appear to be different in at least two respects: 1) the P-adrenergitally induced secrets are relatively scanty compared with cholinergically induced secrets (4, 28, 29), 2) only the P-adrenergic, not cholinergic, secrets are affected in cystic fibrosis (CF) (29). We do not know the electrophysiological mechanisms employed by these two major physiological stimuli to explain the difference in fluid volume secret, nor do we underst why the genetic defect in CF has such a discriminating effect on P-adrenergically evoked exocrine secrets. The sweat gl secretory coil is one of the very few model systems in which different physiological mechanisms of secret from an electrophysiologically identified secretory cell can be examined (21,24). We (21,24) have recently shown that the sweat gl secretory coil is made up of three electrophysiologically distinct cell types: the contractile myoepithelial cells, which form an outer sheath around the inner two secretory cell EXOCRINE C486

Journal

AJP - Cell Physiology – The American Physiological Society

Published: Aug 1, 1996

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