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Decreased in vitro secretion of LH, FSH, and free alpha-subunits by pituitary cells from old male rats

Departments of Medicine, Francis Scutt Key Medical Center an.d Johns Hopkins School of Medicine, Endocrinology Section, Clinical Physiology Branch, Gerontology Research Center, National Institute on Aging, Nutional Institutes of Health, Baltimore, Maryl 21224 D, secretion of LH, old male . MARC R., AWRADHA PANAYIOTIS S. MITCHELL HARMAN. Decreased vitro in FSH, free w-subunits by pituitary cells from Am. J. Physiol. 249 (Endocrinol. Metab. 12): E145-E151, 1985.-Various in vivo in vitro pituitaryLeydig cell functions were examinedin mature (5-8 mo) vs. old (Z-25 mo) male Wistar , Old exhibited decreased serum concentrations of testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) (P c 0,0025)but similar levels of prolactin (P > 0.1) both before 4 wk after castration. The in vitro releaseof LH, FSW, free a-subunits was measuredin primary cultures of dispersedanterior pituitary cells from both intact castrated . During 48 h of incubation, basal secretion rates of the glycoproteins were decreased < 0.001) from cells of both intact castrated (P old , After stimulation with LH-releasing hormone (LRH) in single (lo-’ M) or multiple (10-10-1017 doses,the total M) amountsof the glycoproteins secretedwere also lessfrom cells of both intact castrated old . However, repeated measures analysis of variance revealed age-relatedhyporesponsivity to LRH http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

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