METHODS SUBSTANTIAL EVIDENCE has demonstrated that stressinducing stimuli are associated with a suppression (1). However, there is little direct evidence to forge the link between the central nervous system and the system, even though the brain is capable communicating with cells via direct nervous innervation lymphoid tissues (15). For example, noradrenergic fibers the sympathetic nervous system innervate the spleen in which lymphocytes reside (4-6, 15, 24). Lymphocytes have receptors for norepinephrine and epinephrine (7, 8), and these catecholamines can inhibit natural killer cell (NK) cytotoxicity (9), an parameter important in host defense against virally infected and tumor cells (10). Corticotropin-releasing factor (CRF) initiates biological actions within the brain that are observed in response to stress, including effects on behavior (2, 22), the hypothalamic-pituitary-adrenal axis (19,23), and the autonomic nervous system (3). Recently Irwin et al. (12) showed that splenic NK cytotoxicity is reduced after intracerebroventricular (ICV) administration CRF in 0363-6119/M $1.50 Copyright Subjects. Male Wistar albino rats (Charles River) weighing 250-300 g were housed in groups three before experimentation in constant-room-temperature animal facilities. They had continuous access to water and food. Animals were handled daily for a 5min period to allow for sufficient habituation to handling and manipulation
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Nov 1, 1988
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera