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Contribution of paraventricular nucleus to afferent renal nerve pressor response

Contribution of paraventricular nucleus to afferent renal nerve pressor response of Western Ontario, pressor response that has two components: an initial, short-onset rise in AP that is due to the activation of the sympathetic nervous system, and a longer-onset, sustained elevation in AP that is mediated in part by increased circulating levels of vasopressin (8). These data suggest that activation of ARN alters systemic AP by increasing the discharge frequency of hypothalamic magnocellular neurosecretory neurons that synthesize and release vasopressin. In support of this suggestion it has been demonstrated that stimulation of ARN in the cat alters the discharge frequency of neurons in the paraventricular nucleus of the hypothalamus (PVH), whose output pathways were not identified (4, 17). In addition, in the rat the discharge frequency of putative vasopressinergic magnocellular neurosecretory neurons in the supraoptic nucleus has been shown to be selectively increased during stimulation of ARN (21) and during the activation of specific renal receptors (22). Therefore the present study was done to investigate the contribution of PVH magnocellular neurosecretory neurons to the pressor response elicited during stimulation of ARN. In the first series of experiments, singleunit activity was recorded from PVH neurons antidromically activated by stimulation of the neurohypophysis (NH), and the effect of activation of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Contribution of paraventricular nucleus to afferent renal nerve pressor response

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Publisher
The American Physiological Society
Copyright
Copyright © 1988 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
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Abstract

of Western Ontario, pressor response that has two components: an initial, short-onset rise in AP that is due to the activation of the sympathetic nervous system, and a longer-onset, sustained elevation in AP that is mediated in part by increased circulating levels of vasopressin (8). These data suggest that activation of ARN alters systemic AP by increasing the discharge frequency of hypothalamic magnocellular neurosecretory neurons that synthesize and release vasopressin. In support of this suggestion it has been demonstrated that stimulation of ARN in the cat alters the discharge frequency of neurons in the paraventricular nucleus of the hypothalamus (PVH), whose output pathways were not identified (4, 17). In addition, in the rat the discharge frequency of putative vasopressinergic magnocellular neurosecretory neurons in the supraoptic nucleus has been shown to be selectively increased during stimulation of ARN (21) and during the activation of specific renal receptors (22). Therefore the present study was done to investigate the contribution of PVH magnocellular neurosecretory neurons to the pressor response elicited during stimulation of ARN. In the first series of experiments, singleunit activity was recorded from PVH neurons antidromically activated by stimulation of the neurohypophysis (NH), and the effect of activation of

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: Mar 1, 1988

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