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Contribution of brain distortion and displacement to CSF dynamics in experimental brain compression

Contribution of brain distortion and displacement to CSF dynamics in experimental brain compression intracranial mass lesion; cerebrospinal index; compliance; outflow resistance fluid; -volume PROGRESSIVE EXPANSION ofanintracranialmass is accompanied by an increase in intracranial (ICP), slowly at first, but then increasing exponentially as the craniospinal volumetric buffering reserve becomes exhausted (8, 14). To predict this nonlinear ICP response, investigators have characterized the cerebrospinal fluid () -volume relationship in terms of functional parameters determined from controlled volume changes in the space (12, 14, 21). One series of studies, initiated by Marmarou et al. (12, 13), involves a small volume addition to the space from which the following parameters are derived: 1) the -volume index (PVI), a measure of the volumetric buffering capacity of the craniospinal axis; 2) the compliance (C) or its reciprocal, elastance (EC&; 3) THE t Deceased R172 28 September 1989. 0363-6119/91 $1.50 Copyright the resistance to outflow (R,). In this study PVI, C, R, are included under the term . There appears to be a problem with the interpretation of the changes in (PVI, C, R,), as determined by the bolus injection method (12), in the case of the progressive expansion of an epidural balloon. Sullivan et al. (22) proposed that since PVI, E, R, reflect only the changes associated http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Contribution of brain distortion and displacement to CSF dynamics in experimental brain compression

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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
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Abstract

intracranial mass lesion; cerebrospinal index; compliance; outflow resistance fluid; -volume PROGRESSIVE EXPANSION ofanintracranialmass is accompanied by an increase in intracranial (ICP), slowly at first, but then increasing exponentially as the craniospinal volumetric buffering reserve becomes exhausted (8, 14). To predict this nonlinear ICP response, investigators have characterized the cerebrospinal fluid () -volume relationship in terms of functional parameters determined from controlled volume changes in the space (12, 14, 21). One series of studies, initiated by Marmarou et al. (12, 13), involves a small volume addition to the space from which the following parameters are derived: 1) the -volume index (PVI), a measure of the volumetric buffering capacity of the craniospinal axis; 2) the compliance (C) or its reciprocal, elastance (EC&; 3) THE t Deceased R172 28 September 1989. 0363-6119/91 $1.50 Copyright the resistance to outflow (R,). In this study PVI, C, R, are included under the term . There appears to be a problem with the interpretation of the changes in (PVI, C, R,), as determined by the bolus injection method (12), in the case of the progressive expansion of an epidural balloon. Sullivan et al. (22) proposed that since PVI, E, R, reflect only the changes associated

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: Jan 1, 1991

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