deficit provides the best measure the magnitude , during a series repeated stretches contracting muscles, the loss in force is rapid and pround (19, 22). This rapid and pround loss in force may arise from fatigue, including failure the excitation-coupling (E-C) process (2, 30), as well as focal damage to sarcomeres, and possibly to the sarcoplasmic reticulum. As a consequence, immediately after repeated contractions, an interpretation the initial mechanism based on the force deficit may be compromised. In addition to the potential problem âfatigue,â interpretations regarding the mechanical factors responsible for the initiation to whole muscles are compromised by the complexity muscle architecture (7), the focal nature the (6,22,25,26), and the apparent greater susceptibility fast compared with slow muscle fibers to develop an (5,16,19,29). To resolve these issues, our experimental design combined a protocol single stretches (3) with a single permeabilized muscle fiber preparation. Under these circumstances, the complexity whole muscle architecture is removed, precise measures the forces developed can be made in the absence fatigue, and the sites ultrastructural damage can be identified and evaluated without intervening events. Despite the advantages this preparation, the force deficits produced following single stretches permeabilized fiber segments do not address possible
AJP - Cell Physiology – The American Physiological Society
Published: Nov 1, 1996
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