S. HORTON University of Vermont, Burlington, Vermont 05405 GOODYEAR, LAURIE J., PATRICIA A. KING, MICHAEL F. HIRSHMAN, CHARLOTTE M. THOMPSON, ELIZABETH D. HORTON, EDWARD S. HORTON. Contractile activity increases plasma membrane in absence of insulin. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E667-E672, 1990.-To study the interactions between insulin on the skeletal transport system, the hindquarters of male rats were perfused in the absence of insulin, in the presence of insulin (30 mu/ml), during s induced by sciatic nerve stimulation, or during s plus insulin. Compared with control preparations, rates of uptake in the perfused hindquarter were increased by 2.5 2.6-fold in the insulin insulin plus groups, respectively, but not significantly increased in the only preparations. After perfusion, soleus red white gastrocnemius s from the hindquarter were pooled used for the preparation of plasma membranes. Skeletal plasma membrane vesicle transport rates were 2.2 + 0.5,7.9 * 1.7,g.O t 2.2, 10.8 t 2.0 nmolomgprotein-lo s-l (40 mM ), plasma membrane transporter numbers were 4.7 & 0.5, 8.1 2 0.9, 9.1 t 1.0, 8.6 t 0.6 pmol/mg protein in the control, , insulin, insulin plus groups, respectively. The transporttransporter ratio, an indication of plasma membrane transporter intrinsic activity, was increased
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Apr 1, 1990
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