IS a major factor in the development of many physiological psychopathological conditions, such as heart disease. This relationship between is often viewed as being more circumstantial than real has always been a subject of controversy (13, 14, 18, 19, 28, 33). This is due, in part, to the fact that this relationship occurs only under certain circumstances. It would appear that a genetic predisposition is required for to develop as a result of exposure both in humans in animals (18, 28, 33). The borderline hypertensive rat (BHR) constitutes a new strain of rat that is genetically prone to develop when exposed to ful situations (or a diet rich in sodium) (9, 11,27-29,33). These rats are the F1 of the breeding between the spontaneously hypertensive rat (SHR) its normotensive control, the WistarKyoto (WKY) rat. The BHR are considered to be in the high normotensive range for arterial pressure (AP) unless they are exposed to a repetitive (28). Furthermore, this has been shown to persist for up to 3 mo after the cessation of the paradigm (27). Although the preponderance of data suggests that chronic exposure to ful paradigms is capable of increasing the AP in BHR, the mechanisms through
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Mar 1, 1997
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