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reaso for these discrepancies are unclear, but they may be related to differences in protocols and species studied. Previous measurements of Ca balance in mineralocorticoid treated sheep (21) and rats (4) also revealed incoistent changes, but the intake of sodium (Na) (4, 21) and Ca (4) was different from the control. These additional variables complicate data interpretatio. The present studies were therefore performed 1) to evaluate whether DOCA also alters Ca and 2) to study the potential mechanisms mediating these changes. METHODS The experiments were performed on Sprague-Dawley rats weighing between 260 and 300 g (Harlan Breeding Laboratories, Indianapolis, IN). Unless otherwise stated, all animals had been equilibrated for at least 10 days on a synthetic rat diet (ICN, Cleveland, OH), containing 0.87% Ca, 2.5% Na, 0.6% P, and 220 IU vitamin D3 per 100 g of food. Hereafter, it will be called the basic diet. The experimental group was injected daily intramuscularly with 15 mg/kg body weight of DOCA in sesame oil (5 mg/ml), while the control group was injected with an identical volume of the vehicle. Group 1: effects of chronic DOCA on Ca metabolism. Ca hyper; parathyroid excess; rats; 1,25-dihydroxyvitamin hormone; mineralocorticoid D cholecalciferol OF
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Sep 1, 1986
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