Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver

Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver Bergasa, Nora Valeria, Steven L. Sabol, W. Scott Young III, David E. Kleiner, and E. Anthony Jones. Cholestasis is associated with preproenkephalin mRNA in the adult rat liver. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G346-G354, 1995.-Cholestatic liver disease is associated with clinical and experimental findings consistent with increased ergic neuromodulation, increased plasma total activity, and elevated plasma enkephalin concentrations. In contrast to the normal adult rat liver, preproenkephalin mRNA was detected by Northern blotting in of adult rats with cholestasis due to bile duct resection and not in the sham-resected controls. Preprodynorphin mRNA was not detected in of either group, while preproopiomelanocortin mRNA was found in very low levels in both groups. Preproenkephalin mRNA was not expressed in the of rats with acute hepatocellular necrosis induced by thioacetamide. Hybridization histochemistry of cholestatic demonstrated the presence of preproenkephalin mRNA primarily over cells in the periportal areas, some of which appeared to be proliferating bile ductular cells. Immunohistochemical staining of cholestatic liver indicated the production of at least Met-enkephalin in association with preproenkephalin . These findings suggest that the liver itself, by synthesizing enkephalins, contributes directly to the abnormalities of the system reported in cholestasis. hepatic s; nine-enkephalin http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
See Article on Publisher Site

Abstract

Bergasa, Nora Valeria, Steven L. Sabol, W. Scott Young III, David E. Kleiner, and E. Anthony Jones. Cholestasis is associated with preproenkephalin mRNA in the adult rat liver. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G346-G354, 1995.-Cholestatic liver disease is associated with clinical and experimental findings consistent with increased ergic neuromodulation, increased plasma total activity, and elevated plasma enkephalin concentrations. In contrast to the normal adult rat liver, preproenkephalin mRNA was detected by Northern blotting in of adult rats with cholestasis due to bile duct resection and not in the sham-resected controls. Preprodynorphin mRNA was not detected in of either group, while preproopiomelanocortin mRNA was found in very low levels in both groups. Preproenkephalin mRNA was not expressed in the of rats with acute hepatocellular necrosis induced by thioacetamide. Hybridization histochemistry of cholestatic demonstrated the presence of preproenkephalin mRNA primarily over cells in the periportal areas, some of which appeared to be proliferating bile ductular cells. Immunohistochemical staining of cholestatic liver indicated the production of at least Met-enkephalin in association with preproenkephalin . These findings suggest that the liver itself, by synthesizing enkephalins, contributes directly to the abnormalities of the system reported in cholestasis. hepatic s; nine-enkephalin

Journal

AJP - Gastrointestinal and Liver PhysiologyThe American Physiological Society

Published: Feb 1, 1995

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