Bergasa, Nora Valeria, Steven L. Sabol, W. Scott Young III, David E. Kleiner, and E. Anthony Jones. Cholestasis is associated with preproenkephalin mRNA in the adult rat liver. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G346-G354, 1995.-Cholestatic liver disease is associated with clinical and experimental findings consistent with increased ergic neuromodulation, increased plasma total activity, and elevated plasma enkephalin concentrations. In contrast to the normal adult rat liver, preproenkephalin mRNA was detected by Northern blotting in of adult rats with cholestasis due to bile duct resection and not in the sham-resected controls. Preprodynorphin mRNA was not detected in of either group, while preproopiomelanocortin mRNA was found in very low levels in both groups. Preproenkephalin mRNA was not expressed in the of rats with acute hepatocellular necrosis induced by thioacetamide. Hybridization histochemistry of cholestatic demonstrated the presence of preproenkephalin mRNA primarily over cells in the periportal areas, some of which appeared to be proliferating bile ductular cells. Immunohistochemical staining of cholestatic liver indicated the production of at least Met-enkephalin in association with preproenkephalin . These findings suggest that the liver itself, by synthesizing enkephalins, contributes directly to the abnormalities of the system reported in cholestasis. hepatic s; nine-enkephalin
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Feb 1, 1995
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera