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Chloride secretion across distal airway epithelium: relationship to submucosal gland distribution

Chloride secretion across distal airway epithelium: relationship to submucosal gland distribution MUCUS AND INHALED DEBRIS are cleared from the pulmo- nary via mucociliary clearance mechanisms, the normal funct of which critically depends on the presence of airway surface liquid. Because active is thought to provide the principal driving force for liquid movement across the airway epithelium, surface liquid volume depends upon the magnitude of imbalance between active secret and absorpt across this barrier. Spatial distribut of absorptive and secretory processes within the tracheobronchial tree was proposed more than two decades ago by Kilburn (10). He reasoned that liquid swept by mucociliary from distal (where aggregate cross-sectal airway circumL526 1040-0605/95 $3.00 Copyright 0 ference is enormous) into the proximal large (where the aggregate airway circumference is as much as ZOO,OOO-fold lower) must be reabsorbed to prevent occlus of the airway lumen. Kilburn therefore hypothesized that airway surface liquid is secreted across distal small airway epithelium and swept into the proximal large where it is reabsorbed. This theory is attractive for several reasons. First, absorpt of Na+ has been shown to exceed secret of Cl- in excised large airway epithelium from most species (4, 19). Second, the distal , where secret is presumed to occur, appear to be severely affected in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Lung Cellular and Molecular Physiology The American Physiological Society

Chloride secretion across distal airway epithelium: relationship to submucosal gland distribution

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
1040-0605
eISSN
1522-1504
Publisher site
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Abstract

MUCUS AND INHALED DEBRIS are cleared from the pulmo- nary via mucociliary clearance mechanisms, the normal funct of which critically depends on the presence of airway surface liquid. Because active is thought to provide the principal driving force for liquid movement across the airway epithelium, surface liquid volume depends upon the magnitude of imbalance between active secret and absorpt across this barrier. Spatial distribut of absorptive and secretory processes within the tracheobronchial tree was proposed more than two decades ago by Kilburn (10). He reasoned that liquid swept by mucociliary from distal (where aggregate cross-sectal airway circumL526 1040-0605/95 $3.00 Copyright 0 ference is enormous) into the proximal large (where the aggregate airway circumference is as much as ZOO,OOO-fold lower) must be reabsorbed to prevent occlus of the airway lumen. Kilburn therefore hypothesized that airway surface liquid is secreted across distal small airway epithelium and swept into the proximal large where it is reabsorbed. This theory is attractive for several reasons. First, absorpt of Na+ has been shown to exceed secret of Cl- in excised large airway epithelium from most species (4, 19). Second, the distal , where secret is presumed to occur, appear to be severely affected in

Journal

AJP - Lung Cellular and Molecular Physiology – The American Physiological Society

Published: Mar 1, 1995

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