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PHYSIOLOGY 6, December 1973. Fâ~intd in U.S.A. Cerebrospinal in keto fluid acid-base relationships lactic CLEMENT E. JR., ROBERTA M. JOHN J. VECCHICNE, EDWIN E. D@artment of Medicine, New Yurk University Shol of Medicine, BeLleme Hospital Chest Service, New York City 10016 E., JR., ROBERTA M. JOHN J. E. , Cerebrospinal @id acid-base relationhps in keto lactic . J. Appl. Physiol. 35 (6) : 813-819. 1973.-The role of ketone bodies lactic acid in central nervous system (CNS) acid-base homeostasis was examined in patients with keto lactic . Before therapy, the change in pH, bicarbonate, total organic acid concentrations (sum of P-hydroxybutyrate, acetoacetate, lactate) was less in cerebrospinal fluid () than in plasma. bicarbonate concentration, both prior to during therapy, was an inverse function of total organic acid concentration. Marked reduction of pH was observed in association with the lowest bicarbonate highest total organic acid concentrations. These data provide evidence that the blood-brain barrier limits entry of organic acids into the during development of keto lactic retards their clearance during recovery, Reduction in bicarbonate concentration is the consequence of titration by organic acids. Failure of compensation for the resulting metabolic is the result of inadequate Pcoz adjustments. CLEMENT, VECCHTONE, EDWIN
Journal of Applied Physiology – The American Physiological Society
Published: Dec 1, 1973
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