Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Cerebrospinal fluid acid-base relationships in ketoacidosis and lactic acidosis

Cerebrospinal fluid acid-base relationships in ketoacidosis and lactic acidosis PHYSIOLOGY 6, December 1973. F’~intd in U.S.A. Cerebrospinal in keto fluid acid-base relationships lactic CLEMENT E. JR., ROBERTA M. JOHN J. VECCHICNE, EDWIN E. D@artment of Medicine, New Yurk University Shol of Medicine, BeLleme Hospital Chest Service, New York City 10016 E., JR., ROBERTA M. JOHN J. E. , Cerebrospinal @id acid-base relationhps in keto lactic . J. Appl. Physiol. 35 (6) : 813-819. 1973.-The role of ketone bodies lactic acid in central nervous system (CNS) acid-base homeostasis was examined in patients with keto lactic . Before therapy, the change in pH, bicarbonate, total organic acid concentrations (sum of P-hydroxybutyrate, acetoacetate, lactate) was less in cerebrospinal fluid () than in plasma. bicarbonate concentration, both prior to during therapy, was an inverse function of total organic acid concentration. Marked reduction of pH was observed in association with the lowest bicarbonate highest total organic acid concentrations. These data provide evidence that the blood-brain barrier limits entry of organic acids into the during development of keto lactic retards their clearance during recovery, Reduction in bicarbonate concentration is the consequence of titration by organic acids. Failure of compensation for the resulting metabolic is the result of inadequate Pcoz adjustments. CLEMENT, VECCHTONE, EDWIN http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Cerebrospinal fluid acid-base relationships in ketoacidosis and lactic acidosis

Loading next page...
 
/lp/the-american-physiological-society/cerebrospinal-fluid-acid-base-relationships-in-ketoacidosis-and-lactic-LH3LgVY7mK

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 1973 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
See Article on Publisher Site

Abstract

PHYSIOLOGY 6, December 1973. F’~intd in U.S.A. Cerebrospinal in keto fluid acid-base relationships lactic CLEMENT E. JR., ROBERTA M. JOHN J. VECCHICNE, EDWIN E. D@artment of Medicine, New Yurk University Shol of Medicine, BeLleme Hospital Chest Service, New York City 10016 E., JR., ROBERTA M. JOHN J. E. , Cerebrospinal @id acid-base relationhps in keto lactic . J. Appl. Physiol. 35 (6) : 813-819. 1973.-The role of ketone bodies lactic acid in central nervous system (CNS) acid-base homeostasis was examined in patients with keto lactic . Before therapy, the change in pH, bicarbonate, total organic acid concentrations (sum of P-hydroxybutyrate, acetoacetate, lactate) was less in cerebrospinal fluid () than in plasma. bicarbonate concentration, both prior to during therapy, was an inverse function of total organic acid concentration. Marked reduction of pH was observed in association with the lowest bicarbonate highest total organic acid concentrations. These data provide evidence that the blood-brain barrier limits entry of organic acids into the during development of keto lactic retards their clearance during recovery, Reduction in bicarbonate concentration is the consequence of titration by organic acids. Failure of compensation for the resulting metabolic is the result of inadequate Pcoz adjustments. CLEMENT, VECCHTONE, EDWIN

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Dec 1, 1973

There are no references for this article.