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- Publisher
- The American Physiological Society
- Copyright
- Copyright © 2012 the American Physiological Society
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- DOI
- 10.1152/ajpregu.00145.2012
- pmid
- 22696574
- Publisher site
- See Article on Publisher Site
Abstract
In the brains of teleosts, angiotensin II (ANG II), one of the main effector peptides of the renin-angiotensin system, is implicated in various physiological functions notably body fluid and electrolyte homeostasis and cardiovascular regulation, but nothing is known regarding the potential action of ANG II and other angiotensin derivatives on ventilation. Consequently, the goal of the present study was to determine possible ventilatory and cardiovascular effects of intracerebroventricular injection of picomole doses (5–100 pmol) of trout (Asn 1 )-ANG II, (Asp 1 )-ANG II, ANG III, ANG IV, and ANG 1–7 into the third ventricle of unanesthetized trout. The central actions of these peptides were also compared with their ventilatory and cardiovascular actions when injected peripherally. Finally, we examined the presence of (Asn 1 )-ANG II, (Asp 1 )-ANG II, ANG III, and ANG IV in the brain and plasma using radioimmunoassay coupled with high-performance liquid chromatography. After intracerebroventricular injection, (Asn 1 )-ANG II and (Asp 1 )-ANG II two ANG IIs, elevated the total ventilation through a selective stimulatory action on the ventilation amplitude. However, the hyperventilatory effect of (Asn 1 )-ANG II was threefold higher than the effect of (Asp 1 )-ANG II at the 50-pmol dose. ANG III, ANG IV, and ANG 1–7 were without effect. In addition, ANG IIs and ANG III increased dorsal aortic blood pressure (P DA ) and heart rate (HR). After intra-arterial injections, none of the ANG II peptides affected the ventilation but (Asn 1 )-ANG II, (Asp 1 )-ANG II, and ANG III elevated P DA (50 pmol: +80%, +58% and +48%, respectively) without significant decrease in HR. In brain tissue, comparable amounts of (Asn 1 )-ANG II and (Asp 1 )-ANG II were detected (ca. 40 fmol/mg brain tissue), but ANG III was not detected, and the amount of ANG IV was about eightfold lower than the content of the ANG IIs. In plasma, ANG IIs were also the major angiotensins (ca. 110 fmol/ml plasma), while significant but lower amounts of ANG III and ANG IV were present in plasma. In conclusion, our study suggests that the two ANG II isoforms produced within the brain may act as a neurotransmitter and/or neuromodulator to regulate the cardioventilatory functions in trout. In the periphery, two ANG IIs and their COOH-terminal peptides may act as a circulating hormone preferentially involved in cardiovascular regulations. ventilatory control heart rate and blood pressure intracerebroventricular injection teleost Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print June 13, 2012 , doi: 10.1152/ajpregu.00145.2012 AJP - Regu Physiol August 1, 2012 vol. 303 no. 3 R311-R320 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpregu.00145.2012v1 303/3/R311 most recent Classifications Neural Control Respiration Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Lancien, F. Articles by Le Mével, J. C. PubMed PubMed citation Articles by Lancien, F. Articles by Le Mével, J. C. Related Content Load related web page information Current Content August 1, 2012 Alert me to new issues of AJP - Regu Physiol About the Journal Calls for Papers Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0363-6119 Online ISSN: 1522-1490 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); } catch(err) {} var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-30"); pageTracker._setDomainName(".physiology.org"); pageTracker._trackPageview(); } catch(err) {}
Journal
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Aug 1, 2012