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Central adaptation to inspiratory-inhibiting expiratory-prolonging vagal input

Central adaptation to inspiratory-inhibiting expiratory-prolonging vagal input In a recent communicon (19) we reported on the temporal changes in ipiratory-inhibiting effect in the course of a brief (-1.0 s) vagal ipiratory-inhibiting . We found that the effect of the increases progressively, reaching a maximum -0.8 s after applicon. Thereafter, the effect of the declines. In the present communicon we describe the respoe dynamics in the course of much longer stimuli (-20 s). In addition, we report on the changes in excitability of the timing mechanisms in the immediate (Cl.0 s) and late (l-20 s) post periods. METHODS Twenty-three cats (3.0-5.0 kg) were studied. All cats were anesthetized with pentobarbital sodium. The initial dose was 35 mg/kg ip. Subsequently, anesthesia was maintained with an intravenous drip of pentobarbital. Catheters were ierted in a femoral vein and a femoral artery for intravenous drug administron and monitoring of arterial blood pressure, respectively. A tracheotomy was performed, and a Z-in. segment of each vagus nerve was dissected. The n.erves were cut distally. Subsequent preparon varied depending on experimental protocol. Protocol I. Changes in Ipiratory Off-Switch Excitability in Immediate Post Period In eight experiments a pair of plnum electrodes was ierted in the diaphragm through an abdominal incision which was http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Central adaptation to inspiratory-inhibiting expiratory-prolonging vagal input

Journal of Applied Physiology , Volume 59: 1072 – Oct 1, 1985

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Publisher
The American Physiological Society
Copyright
Copyright © 1985 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
See Article on Publisher Site

Abstract

In a recent communicon (19) we reported on the temporal changes in ipiratory-inhibiting effect in the course of a brief (-1.0 s) vagal ipiratory-inhibiting . We found that the effect of the increases progressively, reaching a maximum -0.8 s after applicon. Thereafter, the effect of the declines. In the present communicon we describe the respoe dynamics in the course of much longer stimuli (-20 s). In addition, we report on the changes in excitability of the timing mechanisms in the immediate (Cl.0 s) and late (l-20 s) post periods. METHODS Twenty-three cats (3.0-5.0 kg) were studied. All cats were anesthetized with pentobarbital sodium. The initial dose was 35 mg/kg ip. Subsequently, anesthesia was maintained with an intravenous drip of pentobarbital. Catheters were ierted in a femoral vein and a femoral artery for intravenous drug administron and monitoring of arterial blood pressure, respectively. A tracheotomy was performed, and a Z-in. segment of each vagus nerve was dissected. The n.erves were cut distally. Subsequent preparon varied depending on experimental protocol. Protocol I. Changes in Ipiratory Off-Switch Excitability in Immediate Post Period In eight experiments a pair of plnum electrodes was ierted in the diaphragm through an abdominal incision which was

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Oct 1, 1985

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