Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Cellular mechanisms in shock and ischemia and their correction

Cellular mechanisms in shock and ischemia and their correction alterations in mitochondrial cation contents, increasedmitochondrial free fatty acidsand Ca2+, and decreased adeninenucleotide translocaseactivity. The cell membranetransport of Na’ and K’, transmembranepotential, cellular ATP and cyclic nucleotide levels, and other phenomenaare also significantly altered. The potential mechanismsresponsible for altered mitochondrial and cellular functions during shock and the consequences of such alterations are discussed. Based on the cellular alterations that occur during shock, attempts have been made to support cell function during such conditions. These (along with volume replacement) include substrates, membrane-stabilizing solutions, and energy compounds.Although provision of’ substrates may improve cellular energy levels, they may not necessarily improve microcirculation. The use of ATP-MgC12 as an adjunct in the treatment of shock and ischemia has been described, and potential mechanisms of the beneficial effects of this compound are discussed. ATP-MgCl,; cellular functions; insulin; reticuloendothelial system becomes a critical series of the organ and the individual. As a result of prolonged reduction in tissue E. D. Churchill (1972) perfusion, various alterations in tissue metabolism, structure, and function occur at the systemic, cellular, Shrlc~k is the state follswing injury which is characterized by a fall in and subcellular levels. Although much has been learned ~nwg~~ produtmtion. about the function and structure http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Cellular mechanisms in shock and ischemia and their correction

Download PDF
18 pages

Loading next page...
 
/lp/the-american-physiological-society/cellular-mechanisms-in-shock-and-ischemia-and-their-correction-z782DWd65J

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 1983 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
See Article on Publisher Site

Abstract

alterations in mitochondrial cation contents, increasedmitochondrial free fatty acidsand Ca2+, and decreased adeninenucleotide translocaseactivity. The cell membranetransport of Na’ and K’, transmembranepotential, cellular ATP and cyclic nucleotide levels, and other phenomenaare also significantly altered. The potential mechanismsresponsible for altered mitochondrial and cellular functions during shock and the consequences of such alterations are discussed. Based on the cellular alterations that occur during shock, attempts have been made to support cell function during such conditions. These (along with volume replacement) include substrates, membrane-stabilizing solutions, and energy compounds.Although provision of’ substrates may improve cellular energy levels, they may not necessarily improve microcirculation. The use of ATP-MgC12 as an adjunct in the treatment of shock and ischemia has been described, and potential mechanisms of the beneficial effects of this compound are discussed. ATP-MgCl,; cellular functions; insulin; reticuloendothelial system becomes a critical series of the organ and the individual. As a result of prolonged reduction in tissue E. D. Churchill (1972) perfusion, various alterations in tissue metabolism, structure, and function occur at the systemic, cellular, Shrlc~k is the state follswing injury which is characterized by a fall in and subcellular levels. Although much has been learned ~nwg~~ produtmtion. about the function and structure

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: Aug 1, 1983

There are no references for this article.