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Cell volume regulation in hemoglobin CC and AA erythrocytes

Cell volume regulation in hemoglobin CC and AA erythrocytes LEE R. BERKOWITZ AND EUGENE P. ORRGER Division of Hematokgy, Department of Medice, School of Medice, University of North Carola, Chapel Hill, North Carola 27514 BERKOWITZ, LEE R., AND EUGENE P. ORRGER. Cell erythrocytes. Am. J. Physiol. 252 (Cell Physiol. 21): C3OOC306, 1987.-Swellg CC erythrocytes stimulates a ouaba-sensitive K flux that restores origal cell . This regulatory pathway was characterized for its anion dependence, sensitivity to loop diuretics, and requirement for Na. The swellg-duced K flux was elimated if tracellular chloride was replaced by nitrate and both swellg-activated K flux and efflux werepartially hibited by 1 mM furosemide or bumetanide. K flux swollen CC was not dimished when Na the cubation medium was replaced with chole, dicatg Na dependence of the swellg-duced flux. Identical experiments with also demonstrated a swellgduced crease K flux, but the magnitude and duration of this crease were considerably less than that seen with CC . The creased K flux was likewise sensitive to anion replacement and to loop diuretics and did not require the presence of Na. These data dicate that a -acti .vated K pathway with simila .r trans port cha racteri sties exists both . ; transport CC ; K b http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Cell volume regulation in hemoglobin CC and AA erythrocytes

L. R. Berkowitz and E. P. Orringer
AJP - Cell Physiology , Volume 252: C300 – Mar 1, 1987
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Publisher
The American Physiological Society
Copyright
Copyright © 1987 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
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Abstract

LEE R. BERKOWITZ AND EUGENE P. ORRGER Division of Hematokgy, Department of Medice, School of Medice, University of North Carola, Chapel Hill, North Carola 27514 BERKOWITZ, LEE R., AND EUGENE P. ORRGER. Cell erythrocytes. Am. J. Physiol. 252 (Cell Physiol. 21): C3OOC306, 1987.-Swellg CC erythrocytes stimulates a ouaba-sensitive K flux that restores origal cell . This regulatory pathway was characterized for its anion dependence, sensitivity to loop diuretics, and requirement for Na. The swellg-duced K flux was elimated if tracellular chloride was replaced by nitrate and both swellg-activated K flux and efflux werepartially hibited by 1 mM furosemide or bumetanide. K flux swollen CC was not dimished when Na the cubation medium was replaced with chole, dicatg Na dependence of the swellg-duced flux. Identical experiments with also demonstrated a swellgduced crease K flux, but the magnitude and duration of this crease were considerably less than that seen with CC . The creased K flux was likewise sensitive to anion replacement and to loop diuretics and did not require the presence of Na. These data dicate that a -acti .vated K pathway with simila .r trans port cha racteri sties exists both . ; transport CC ; K b

Journal

AJP - Cell Physiology – The American Physiological Society

Published: Mar 1, 1987

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