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METHODS AND PROCEDURE cardiovascular effects of effects of CO,; effects after hexamethonium of after propranolol; ODERATE ELEVATIONS of Pcoz in arterial blood have been associated with vasoconstriction and changes in cardiac output and heart rate. These alterations are thought to be secondary to central nervous system stimulation resulting in a generalized sympathetic discharge connections are (5, 6, 119 I 2). If efferent sympathetic interrupted, or if peripheral vasoconstrictor receptors are blocked, the same stimulus causes vasodilatation (9). Changes in cardiac output and peripheral vasodilatation suggest that these effects of carbon dioxide may be mediated through stimulation of beta-adrenergic receptors. Received for publication I August 1966. 1 This study was supported by grants from the National Institutes of Health (HE-02644 and HE-og835), the Iowa Thoracic Society, and Research Career Program Awards HE-K6-4626 and HE-K3I 7013 from the National Heart Institute. â23 The experiments were done on 30 male mongrel dogs ranging in weight from 12 to 22 kg. The animals were anesthetized with chloralose (50 mg/kg), and urethan (500 âg/kg), treated with decamethonium bromide (0.3 âg/kg), intubated and ventilated with a Harvard respiratory pump. Ventilation was adjusted at the beginning of the experiment so that end-expiratory carbon dioxide concentration
Journal of Applied Physiology – The American Physiological Society
Published: Feb 1, 1967
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