Cardiac remodeling in aortic and mitral valve disease: a simulation study with clinical validation

Cardiac remodeling in aortic and mitral valve disease: a simulation study with clinical validation Cardiovascular simulations with adaptive feedback that normalizes wall shear stress and fiber stress in the cardiac chambers could predict, in a quantitative and qualitative manner, remodeling patterns seen in patients with left-sided valvular disease. This highlights how mechanical stress remains a fundamental aspect of cardiac remodeling. This in silico study validated with clinical data paves the way for future patient-specific predictions of remodeling in valvular disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Cardiac remodeling in aortic and mitral valve disease: a simulation study with clinical validation

Journal of Applied Physiology, Volume 126 (5) – May 1, 2019

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ISSN
8750-7587
eISSN
1522-1601
D.O.I.
10.1152/japplphysiol.00791.2018
Publisher site
See Article on Publisher Site

Abstract

Cardiovascular simulations with adaptive feedback that normalizes wall shear stress and fiber stress in the cardiac chambers could predict, in a quantitative and qualitative manner, remodeling patterns seen in patients with left-sided valvular disease. This highlights how mechanical stress remains a fundamental aspect of cardiac remodeling. This in silico study validated with clinical data paves the way for future patient-specific predictions of remodeling in valvular disease.

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: May 1, 2019

References

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