Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Cardiac muscle mechanics from Doca- and aging spontaneously hypertensive rats

Cardiac muscle mechanics from Doca- and aging spontaneously hypertensive rats of Minrtesota School of Medicine, HELLER, LOIS JANE. mX*h~?lk*~ fkm Dma- trrd trg-irg qxm tmwwsly hyxv*terwiw rnts. Am. J. Physiol. 235W: H13ZH86, 1978 or Am. J. Physiol.: Heart Circ. Physiol. 44 1): HWH86, 1978. -Contractile properties of isolated papillary muscles from three age groups of spontaneously hypertensive rats (s) were compared to those from age-matched Wistar-Kyoto rats (s) to assess whether- there were differences between the &rains preceding and during the course of the hypertension. In alI three age groups (7, 12, and 50 wk), the mechanical refractory periods IMRPI were longer and aftercontractions more prominent after paired pulse stimulation in preparations from s than from age-matched s. Other isometric twitch properties of papillary muscles at L,,,,,, were not different from s, with the exception of a shorter half-relaxation time in the youngest group. Although hypertension and cardiac hypertrophy increased in s with age, aging had similar influences on most cardiac contractile properties in both strains. None of the isometric properties of papillary muscles from rats made hypertensive by Doca treatment were different from those in normotensive control preparations. This suggests that differences seen between s and s probably represent genetic differences between these strains and are not http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Cardiac muscle mechanics from Doca- and aging spontaneously hypertensive rats

AJP - Heart and Circulatory Physiology , Volume 235: H82 – Jul 1, 1978

Loading next page...
 
/lp/the-american-physiological-society/cardiac-muscle-mechanics-from-doca-and-aging-spontaneously-9fSG0zCa50
Publisher
The American Physiological Society
Copyright
Copyright © 1978 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

of Minrtesota School of Medicine, HELLER, LOIS JANE. mX*h~?lk*~ fkm Dma- trrd trg-irg qxm tmwwsly hyxv*terwiw rnts. Am. J. Physiol. 235W: H13ZH86, 1978 or Am. J. Physiol.: Heart Circ. Physiol. 44 1): HWH86, 1978. -Contractile properties of isolated papillary muscles from three age groups of spontaneously hypertensive rats (s) were compared to those from age-matched Wistar-Kyoto rats (s) to assess whether- there were differences between the &rains preceding and during the course of the hypertension. In alI three age groups (7, 12, and 50 wk), the mechanical refractory periods IMRPI were longer and aftercontractions more prominent after paired pulse stimulation in preparations from s than from age-matched s. Other isometric twitch properties of papillary muscles at L,,,,,, were not different from s, with the exception of a shorter half-relaxation time in the youngest group. Although hypertension and cardiac hypertrophy increased in s with age, aging had similar influences on most cardiac contractile properties in both strains. None of the isometric properties of papillary muscles from rats made hypertensive by Doca treatment were different from those in normotensive control preparations. This suggests that differences seen between s and s probably represent genetic differences between these strains and are not

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Jul 1, 1978

There are no references for this article.