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Calcium entry in rat parotid acini: activation by carbachol and aluminum fluoride

MERTZ,LAWRENCE M., VALERIE J. HORN,BRUCE J. BAUM, AND INDU S. AMBUDKAR. Calcium in rat parotid acini: by achol and aluminum fluoride. Am. J. Physiol. 258 (Cell Physiol. 27): C654-C661, 1990.- extracellular Ca2’ into the cytosol exocrine cells plays an important role in the process fluid transport, especially during periods prolonged secretion. However, in parotid acinar cells, the process and the identity factors which regulate it remain obscure. In this report, we demonstrate that AlF;, like achol, activates Ca2’ into dispersed rat parotid acini. In physiological -containing (1.28 mM) medium, both agents elicit three phases cytosolic Ca2’ change, an initial transient increase (intracellular dependent) followed sequentially by a decrease (intra- and extracellular dependent) and a small sustained increase (extracellular dependent). Cytosolic concentration ( [ Ca”‘];) during the last two phases is influenced by variations in extracellular [Ca”+]. Elevation extracellular [Ca”+], at any time after the initial transient increase, results in a rise cytosolic [Ca”‘], thus demonstrating the existence a pathway during the two later phases. These data suggest the likelihood that in parotid acini, G protein is involved in stimulating this Ca2’ pathway. Because in AlF;-treated acini into the cytosol is detectable only after the initial intracellular release phase, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

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