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C-type natriuretic peptides stimulate chloride secretion in the rectal gland of Squalus acanthias

AND P. SILVA New En Deaconess Hospital and Beth Israel Hospital, Boston, Massachusetts 02215; SCIOS, Mountain View, California 94043; and Mount Desert Island Biological Laboratory, Salsbury Cove, Maine 04672 Solomon, R., A. Protter, G.McEnroe, J. G. Porter, and P. Silva. C-type natriuretic peptides stimulate chloride secretion in of Squab acanthias. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R707R711, 1992.-Homologous shark C-type natriuretic peptide (sCNP) wasinfused asa bolusand asa constant infusion in the isolated perfused rectal of the same species,Squalus acanthias. sCNP was a potent stimulator of chloride secretion similar in its dose-response curve to vasoactive intestinal peptide. sCNP was equipotent with killifish CNP but more potent than human CNP (hCNP). Truncated and substituted, forms of hCNP were also capable of stimulation of chloride secretionin the order hCNP > hCNP (6-22) = [Glyg] hCNP > hCNP-( 7- 21). sCNP wasmorepotent than human atria1natriuretic peptide (hANP), which was more potent than porcine brain natriuretic peptide. hANP-(31-67) was without effect. These studiessuggest that sCNP may be the physiological regulator of rectal function. The receptor in is unknown but based the order of potencies,position 4 in the on NH,-terminal end and the ring itself are important for ligand effects. vasoactive http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

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