BACAL, AND DIANA L. KUNZE Texas 77030 Dertment Physiology and Biophysics, Baylor College of Medicine, Houston, Mendelowitz, David, Kira Bacal, and Diana L. Kunze. thway in bovine aortic endothelial cells. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H942-H948,1992.-Clusters of electrically coupled endothelial cells were used to characterize a bradykinin (BK)-activated Ca2+ thway. Stial voltage control of clusters containing three to eight cells, evaluated as the ratio of the voltage response in one cell to a voltage pulse in the most distant cell of the cluster, was 0.96 at a holding potential of 0 mV in normal saline bath and 0.88 in the presence of BK. BK activated an inward current that was carried by either Naâ or Ca2+ when the membrane potential was held at mV. Current was activated within 3 s of application of BK and peaked within 1 min. With Ca2+as the permeable extracellular ion the current was stable for l-3 min and then declined over a period of 5-8 min in the continued presence of BK. However, when Naâ carried the current it was sustained over a lo-min test period. The reversal potential of the BK-activated current was near 0 mV, suggesting activation of
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Apr 1, 1992
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