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Blunted hypoxic vasoconstriction in oleic acid lung injury: effect of cyclooxygenase inhibitors

Blunted hypoxic vasoconstriction in oleic acid lung injury: effect of cyclooxygenase inhibitors METHODS PULMONARY (HPV) is an intrapulmonary process that diverts blood flow away from lung regions, resulting in a better matching of perfusion to ventilation and less arterial hypoxemia. We recently showed (21) that aspirin and indomethacin accentuated pulmonary hypertension and improved gas exchange in dogs with permeability edema induced by oleic acid (OA). Similar results have been reported with meclofenamate in the same experimental model (27). These studies suggest that a vasodilating prostaglandin is released during lung injury and contributes to altered gas exchange by inhibiting HPV. Impairment of HPV has been described in various Twenty-six mongrel dogs (19-40 kg, mean 29 kg) were anesthetized with pentobarbital sodium (25 mg/kg iv), paralyzed with pancuronium bromide (0.2 mg/kg iv), and ventilated (Elema 900 B servo-ventilator, Siemens) via a cuffed endotracheal tube; the FI,, was 0.4, the respiratory rate was 12 breathsimin, and the tidal volume of 15-20 ml/kg was adjusted to maintain arterial Pcoz between 30 and 40 Torr. Periodic deep inspirations were administered to prevent atelectasis formation. Pentobarbital sodium (2 mg/kg iv) and pancuronium (0.2 mgl kg iv) were repeated hourly to maintain anesthesia and apnea. Throughout the experiments, 5% dextrose in 0.45% NaCl was infused in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Blunted hypoxic vasoconstriction in oleic acid lung injury: effect of cyclooxygenase inhibitors

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Publisher
The American Physiological Society
Copyright
Copyright © 1992 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

METHODS PULMONARY (HPV) is an intrapulmonary process that diverts blood flow away from lung regions, resulting in a better matching of perfusion to ventilation and less arterial hypoxemia. We recently showed (21) that aspirin and indomethacin accentuated pulmonary hypertension and improved gas exchange in dogs with permeability edema induced by oleic acid (OA). Similar results have been reported with meclofenamate in the same experimental model (27). These studies suggest that a vasodilating prostaglandin is released during lung injury and contributes to altered gas exchange by inhibiting HPV. Impairment of HPV has been described in various Twenty-six mongrel dogs (19-40 kg, mean 29 kg) were anesthetized with pentobarbital sodium (25 mg/kg iv), paralyzed with pancuronium bromide (0.2 mg/kg iv), and ventilated (Elema 900 B servo-ventilator, Siemens) via a cuffed endotracheal tube; the FI,, was 0.4, the respiratory rate was 12 breathsimin, and the tidal volume of 15-20 ml/kg was adjusted to maintain arterial Pcoz between 30 and 40 Torr. Periodic deep inspirations were administered to prevent atelectasis formation. Pentobarbital sodium (2 mg/kg iv) and pancuronium (0.2 mgl kg iv) were repeated hourly to maintain anesthesia and apnea. Throughout the experiments, 5% dextrose in 0.45% NaCl was infused in the

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Jan 1, 1992

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