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I. INTRODUCTION The first major review on the physiology of adipose tissue was that of Wertheimer and Shapiro in 1948 (165). They concluded that adipose tissue is supplied by a comparatively dense network of capillaries, a conclusion based mainly on quantitative data from Gersh and Still (72). Apart from data based on histological techniques, there was no information concerning blood flow in adipose tissue at that time. The next major review on adipose tissue appeared in 1965 as a section of the Handbook of Physiology (149, 152, 155). The rapid development of adipose tissue physiology during the intervening period was amply demonstrated by the over 4,000 references, compared with 90 in the earlier review. In the meantime, in 1956 Dole (46) and Gordon and Cherkes (74) recognized the great physiological importance of the free fatty acid (FFA) fraction in blood. Therefore it was possible to study the mobilization of fat from adipose tissue and to investigate how fat is transported in the blood to be oxidized in various organs. The mobilization of FFA is due to lipolysis, i.e., hydrolysis, of triglycerides stored 1078 0031-9333/79/000000-00$01.25 Copyright 0 1979 the American Physiological Society October BLOOD FLOW AND ADIPOSE TISSUE in
Physiological Reviews – The American Physiological Society
Published: Oct 1, 1979
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