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Biosynthesis of acetylcholine in nervous tissue

Biosynthesis of acetylcholine in nervous tissue CATHERINE Agricultural Research Council, in HEBB Institute of Animal England 918 920 920 921 925 928 928 930 933 934 937 937 942 947 Physiology, Babraham, Cambridge, I. Introduction ........................................................ II. Development of radiometric assays for choline . ........... A. Coupled systems for enzymic production of acetyl-CoA. .............. B. Synthetic acetyl-CoA as substrate. ................................. III. Quantitative assays of choline based on [i4C]acetyl-CoA. ... IV. Properties of choline and molecular basis of its action. ..... A. Kinetic properties of ChAc....................................... B. Sulphydryl groups and enzyme function. ........................... C. Specific inhibitors of choline ....................... V. Subcellular distribution of choline in nervous tissue. ....... VI. Synthesis of acetylcholine in nerve endings and their structural components. .. A. Source of substrates. ............................................ B. Possible sites for synthesis of acetylcholine within the nerve ending. ..... VII. Implications for the vesicular hypothesis. ............................... I. INTRODUCTION Although, as its natural distribution implies, acetylcholine (ACh) must have other as yet unknown functions, its function as a neurotransmitter is the one that can be most certainly identified and still compels the greatest interest. That it is a neurotransmitter, released by certain groups of neurons, which by this release are defined as cholinergic neurons, is now generally accepted; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reviews The American Physiological Society

Biosynthesis of acetylcholine in nervous tissue

C. Hebb
Physiological Reviews , Volume 52: 918 – Oct 1, 1972
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Publisher
The American Physiological Society
Copyright
Copyright © 1972 the American Physiological Society
ISSN
0031-9333
eISSN
1522-1210
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Abstract

CATHERINE Agricultural Research Council, in HEBB Institute of Animal England 918 920 920 921 925 928 928 930 933 934 937 937 942 947 Physiology, Babraham, Cambridge, I. Introduction ........................................................ II. Development of radiometric assays for choline . ........... A. Coupled systems for enzymic production of acetyl-CoA. .............. B. Synthetic acetyl-CoA as substrate. ................................. III. Quantitative assays of choline based on [i4C]acetyl-CoA. ... IV. Properties of choline and molecular basis of its action. ..... A. Kinetic properties of ChAc....................................... B. Sulphydryl groups and enzyme function. ........................... C. Specific inhibitors of choline ....................... V. Subcellular distribution of choline in nervous tissue. ....... VI. Synthesis of acetylcholine in nerve endings and their structural components. .. A. Source of substrates. ............................................ B. Possible sites for synthesis of acetylcholine within the nerve ending. ..... VII. Implications for the vesicular hypothesis. ............................... I. INTRODUCTION Although, as its natural distribution implies, acetylcholine (ACh) must have other as yet unknown functions, its function as a neurotransmitter is the one that can be most certainly identified and still compels the greatest interest. That it is a neurotransmitter, released by certain groups of neurons, which by this release are defined as cholinergic neurons, is now generally accepted;

Journal

Physiological Reviews – The American Physiological Society

Published: Oct 1, 1972

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