GALEN M. PIEPER, DAVID A. MEI, PETER LANGENSTROER, AND STEPHEN T. OâROURKE Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 Pieper, Galen M., David A. Mei, Peter Langenstroer, and Stephen T. OâRourke. of endothelium-derived relaxing factor in diabetic rat aorta. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H676-H680,1992.-The bioasssay technique was utilized to quantitate endothelium-derived relaxing factor (EDRF) released from perfuseddonor segments control and of diabetic rat aorta. In the presenceof indomethacin, perfusates of donor segments with endotheliumwere allowedto superfuse recipient detector rings of normal rat aorta without endothelium. Under basalconditions, relaxations of the rings to perfusatesof control and diabetic donor segments were similar. Perfusion of donor segments with acetylcholine produced relaxation of rings, which was decreased from endothelial perfusion of diabetic donor segments. These relaxations were inhibited by addition of methylene blue to the detector ring or by perfusion of donor segments with nitro-L-arginine. Infusion of superoxidedismutase(SOD) at a site proximal to the donor segmentnormalized relaxations induced by acetylcholine addition to diabetic donors. In contrast, infusion of SOD distal to the donor had no effect on acetylcholine-stimulated relaxations of detector rings from control donors while attenuating, paradoxically, the relaxations of detector rings
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Sep 1, 1992
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