Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart

Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the... Premature birth is associated with increased risk for cardiac dysfunction and failure throughout life. Here, we identify bimodal right ventricular dysfunction after postnatal hyperoxia exposure. Mitochondrial biogenesis serves as an early adaptive feature promoting recovery of cardiac hemodynamic and mitochondrial function. However, the accumulation of mitochondrial DNA mutations results in late mitochondrial and right ventricular dysfunction. This bimodal right ventricular dysfunction may have important implications for the development of screening programs in the preterm population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart

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ISSN
0363-6135
eISSN
1522-1539
DOI
10.1152/ajpheart.00383.2019
Publisher site
See Article on Publisher Site

Abstract

Premature birth is associated with increased risk for cardiac dysfunction and failure throughout life. Here, we identify bimodal right ventricular dysfunction after postnatal hyperoxia exposure. Mitochondrial biogenesis serves as an early adaptive feature promoting recovery of cardiac hemodynamic and mitochondrial function. However, the accumulation of mitochondrial DNA mutations results in late mitochondrial and right ventricular dysfunction. This bimodal right ventricular dysfunction may have important implications for the development of screening programs in the preterm population.

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Dec 1, 2019

References

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