bFGF ameliorates focal ischemic injury by blood flow-independent mechanisms in eNOS mutant mice

bFGF ameliorates focal ischemic injury by blood flow-independent mechanisms in eNOS mutant mice Huang, Zhihong, Ke Chen, Paul L. Huang, Seth P. Finklestein, Michael A. Moskowitz. ameliorates ischemic injury by blood flow-independent mechanisms mutant . Am. J. Physiol. 272 (Heart Circ. Physiol. 41): Hl401-H1405, 1996.-Genetically engineered deficient in the expression of type III nitric oxide synthase (NOS) [endothelial NOS (eNOS>] were used to decipher the importance of nitric oxide (NO)-dependent augmentation of regional cerebral blood flow (rCBF) to infarct volume reduction following basic fibroblast growth factor () in f us1‘o n d uring acute middle cerebral artery (MCA) * occlusion. We have shown previously that intravenously administered reduces infarct volume following MCA occlusion in rats that dilates cerebral pial arterioles by NO-dependent mechanisms. Halothane-anesthetized eNOS wild-type were subjected to permanent MCA occlusion by intraluminal filament for 24 h. (100 pg. kg-l+ h-l) was infused intravenously for 2 h, beginning 15 min after the onset of occlusion. Infarct volume was reduced from 119 ? 8 to 93 t 4 mm3 (22% reduction, P < 0.05) or from 102 t 9 to 77 2 6 mm3 (24% reduction, P < 0.05) or wild-type , respectively (means t SE; n = 10 per group), neurological deficits were also significantly reduced. Although infusion caused a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

bFGF ameliorates focal ischemic injury by blood flow-independent mechanisms in eNOS mutant mice

Loading next page...
 
/lp/the-american-physiological-society/bfgf-ameliorates-focal-ischemic-injury-by-blood-flow-independent-URf1oZgWa5
Publisher
The American Physiological Society
Copyright
Copyright © 1997 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

Huang, Zhihong, Ke Chen, Paul L. Huang, Seth P. Finklestein, Michael A. Moskowitz. ameliorates ischemic injury by blood flow-independent mechanisms mutant . Am. J. Physiol. 272 (Heart Circ. Physiol. 41): Hl401-H1405, 1996.-Genetically engineered deficient in the expression of type III nitric oxide synthase (NOS) [endothelial NOS (eNOS>] were used to decipher the importance of nitric oxide (NO)-dependent augmentation of regional cerebral blood flow (rCBF) to infarct volume reduction following basic fibroblast growth factor () in f us1‘o n d uring acute middle cerebral artery (MCA) * occlusion. We have shown previously that intravenously administered reduces infarct volume following MCA occlusion in rats that dilates cerebral pial arterioles by NO-dependent mechanisms. Halothane-anesthetized eNOS wild-type were subjected to permanent MCA occlusion by intraluminal filament for 24 h. (100 pg. kg-l+ h-l) was infused intravenously for 2 h, beginning 15 min after the onset of occlusion. Infarct volume was reduced from 119 ? 8 to 93 t 4 mm3 (22% reduction, P < 0.05) or from 102 t 9 to 77 2 6 mm3 (24% reduction, P < 0.05) or wild-type , respectively (means t SE; n = 10 per group), neurological deficits were also significantly reduced. Although infusion caused a

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Mar 1, 1997

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off