Beneficial actions of CP-0127, a novel bradykinin receptor antagonist, in murine traumatic shock

Beneficial actions of CP-0127, a novel bradykinin receptor antagonist, in murine traumatic shock viral rhinitis, asthma, pain, inflammatory bowel disease, as well as anaphylactic and septic (I, 18, 19). A variety of mediators appear to be involved in the pathophysiology of tic , but the contribution of BK or other kinins is not known. Since 1985, specific BK receptor antagonists have become available. Previous studies have demonstrated the ability of BK antagonists to partially attenuate adverse effects in endotoxic (28,30). However, it is not clear whether administration of BK antagonists can also exert protective effects , which is a very severe form of circulatory that may lead to the death of patients. CP-0127 is a novel and potent homodimer BK antagonist (8) that has recently been shown to block the hypotensive response to endotoxin and increase survival in an animal model of endotoxin (29). The purposes of the present study were to 1) investigate whether CP-0127 is an effective anti agent in a well-established model of tic , and 2) study the mechanisms of the protective effects of CP-0127 if anti effects are observed. MATERIALS AND METHODS (BK) is a vasoactive peptide released by activation of the kallikrein-kinin system and is one of the humoral systems activated in . BK exerts http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Beneficial actions of CP-0127, a novel bradykinin receptor antagonist, in murine traumatic shock

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Publisher
The American Physiological Society
Copyright
Copyright © 1994 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

viral rhinitis, asthma, pain, inflammatory bowel disease, as well as anaphylactic and septic (I, 18, 19). A variety of mediators appear to be involved in the pathophysiology of tic , but the contribution of BK or other kinins is not known. Since 1985, specific BK receptor antagonists have become available. Previous studies have demonstrated the ability of BK antagonists to partially attenuate adverse effects in endotoxic (28,30). However, it is not clear whether administration of BK antagonists can also exert protective effects , which is a very severe form of circulatory that may lead to the death of patients. CP-0127 is a novel and potent homodimer BK antagonist (8) that has recently been shown to block the hypotensive response to endotoxin and increase survival in an animal model of endotoxin (29). The purposes of the present study were to 1) investigate whether CP-0127 is an effective anti agent in a well-established model of tic , and 2) study the mechanisms of the protective effects of CP-0127 if anti effects are observed. MATERIALS AND METHODS (BK) is a vasoactive peptide released by activation of the kallikrein-kinin system and is one of the humoral systems activated in . BK exerts

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Mar 1, 1994

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