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Baroreceptor control of pressure-flow relationships during hypoxemia

of pressure-flow R. H. COX, G. KARREMAN, AND J. NEWSWANGER Irtstitute, of Anesthesiology of Pennsylvania, and Physiology and Bockus Research Philadelphia, Pennsylvania 19104 BAGSHAW, R. J., R. H. Cox, G. KARREMAN, AND J. NEWSBuroreceptor of pressure-flow relationships . J. Appl. Physiol. 60(1):166-175, 1986.-In WANGER. the absenceof peripheral chemoreceptors, effects of graded the on the carotid sinus of central and regional hemodynamicswere studied in anesthetizedmongrel dogs. stimulation was effected by carotid sinus isolation and perfusion under led pressure. Blood flows were measured the aorta and the celiac, mesenteric,left renal, and in right iliac arteries. Carotid sinusreflex set-point pressures were well maintained until was severe. Carotid sinus reflex set-point gain was maximal mild . Reflex operating point regional flows were unaffected by . A factorial analysisof overall reflex increases mean in aortic pressure,flow, and power reduced stimulation showedpotentiation by increasing. Correspondingeffects of stimulation and on aortic resistanceand heart rate were additive. Celiac, renal, and iliac blood flows increased both and reduced stimulation. Only in the celiac bed were blood flow changes independent of concomitant changes in cardiac output. Thus, at maximum sympathetic stimulation (low carotid sinus pressure) , the system maintained both central and regional blood flows at high systemicblood http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

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