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ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species

ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin... REFERENCES 1. ↵ Anderson M , Kim EY , Hagmann H , Benzing T , Dryer SE . Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol . Am J Physiol Cell Physiol 305 : C276 – C289 , 2013 . OpenUrl Abstract / FREE Full Text 2. ↵ Anderson M , Roshanravan H , Khine J , Dryer SE . Angiotensin II activation of canonical transient receptor potential-6 (TRPC6) channels in rat podocytes requires generation of reactive oxygen species . J Cell Physiol 229 : 434 – 442 , 2014 . OpenUrl CrossRef Medline 3. ↵ Bailey MA , Turner CM , Hus-Citharel A , Marchetti J , Imbert-Teboul M , Milner P , Burnstock G , Unwin RJ . P 2 Y receptors present in the native and isolated rat glomerulus . Nephron Physiol 96 : 79 – 90 , 2004 . OpenUrl CrossRef 4. ↵ Boute N , Gribouval O , Roselli S , Benessy F , Lee H , Fuchshuber A , Dahan K , Gubler MC , Niaudet P , Antignac C . NPHS2 , encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome . Nat Gen 24 : 349 – 354 , 2000 . OpenUrl CrossRef Medline Web of Science 5. ↵ Dale N . Dynamic ATP signalling and neural development . J Physiol 586 : 2429 – 2436 , 2008 . OpenUrl Abstract / FREE Full Text 6. ↵ Flockerzi V , Nilius B Dietrich A , Gudermann T . TRPC6 . In: Transient Receptor Potential (TRP) Channels , edited by Flockerzi V , Nilius B . Springer Berlin Heidelberg , 2007 , p. 125 – 141 . 7. ↵ Dryer SE , Reiser J . TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology . Am J Physiol Renal Physiol 299 : F689 – F701 , 2010 . OpenUrl Abstract / FREE Full Text 8. ↵ Eckstein F , Cassel D , Levkovitz H , Lowe M , Selinger Z . Guanosine-O(2-thiodiphosphate): An inhibitor of adenylate cyclase stimulation by guanine nucleotides and fluoride ions . J Biol Chem 254 : 9829 – 9834 , 1979 . OpenUrl FREE Full Text 9. ↵ El-Tayeb A , Qi A , Nicholas RA , Müller CE . Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y 2 , P2Y 4 , and P2Y 6 receptors . J Med Chem 54 : 2878 – 2890 , 2011 . OpenUrl CrossRef Medline 10. ↵ Fischer KG , Saueressig U , Jacobshagen C , Wichelmann A , Pavenstadt H . Extracellular nucleotides regulate cellular functions of podocytes in culture . Am J Physiol Renal Physiol 281 : F1075 – F1081 , 2001 . OpenUrl Abstract / FREE Full Text 11. ↵ Heeringa SF , Möller CC , Du J , Yue L , Hinkes B , Chernin G , Vlangos CN , Hoyer PF , Reiser J , Hildebrandt F . A novel TRPC6 mutation that causes childhood FSGS . PLos One 4 : e7771 , 2009 . OpenUrl CrossRef Medline 12. ↵ Hofmann T , Obukhov AG , Schaefer M , Harteneck C , Gudermann T , Schultz G . Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol . Nature 397 : 259 – 263 , 1999 . OpenUrl CrossRef Medline Web of Science 13. ↵ Höhne M , Ising C , Hagmann H , Völker LA , Brähler S , Schermer B , Brinkkoetter PT , Benzing T . Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions . Am J Pathol 182 : 332 – 338 , 2013 . OpenUrl CrossRef Medline Web of Science 14. ↵ Holstein-Rathlou NH . Oscillations and chaos in renal blood flow control . J Am Soc Nephrol 4 : 1275 – 1287 , 1993 . OpenUrl Abstract 15. ↵ Holstein-Rathlou NH , Wagner AJ , Marsh DJ . Tubuloglomerular feedback dynamics and renal blood flow autoregulation in rats . Am J Physiol Renal Fluid Electrolyte Physiol 260 : F53 – F68 , 1991 . OpenUrl Abstract / FREE Full Text 16. ↵ Homolya L , Watt WC , Lazarowski ER , Koller BH , Boucher RC . Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y 2 receptor (−/−) mice . J Biol Chem 274 : 26454 – 26460 , 1999 . OpenUrl Abstract / FREE Full Text 17. ↵ Huber TB , Schermer B , Müller RU , Höhne M , Bartram M , Calixto A , Hagmann H , Reinhardt C , Koos F , Kunzelmann K , Shirokova E , Krautwurst D , Harteneck C , Simons M , Pavenstädt H , Kerjaschki D , Thiele C , Walz G , Chalfie M , Benzing T . Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels . Proc Natl Acad Sci USA 103 : 17079 – 17086 , 2006 . OpenUrl Abstract / FREE Full Text 18. ↵ Ilatovskaya DV , Palygin O , Levchenko V , Staruschenko A . Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli . Am J Physiol Cell Physiol 305 : C1050 – C1059 , 2013 . OpenUrl Abstract / FREE Full Text 19. ↵ Jung S , Mühle A , Schaefer M , Strotmann R , Schultz G , Plant TD . Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth . J Biol Chem 278 : 3562 – 3571 , 2003 . OpenUrl Abstract / FREE Full Text 20. ↵ Kim EY , Anderson M , Dryer SE . Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species . Am J Physiol Renal Physiol 302 : F298 – F307 , 2012 . OpenUrl Abstract / FREE Full Text 21. ↵ Kim EY , Anderson M , Dryer SE . Sustained activation of N -methyl- d -aspartate receptors in podoctyes leads to oxidative stress, mobilization of transient receptor potential canonical 6 channels, nuclear factor of activated T cells activation, and apoptotic cell death . Mol Pharmacol 82 : 728 – 737 , 2012 . OpenUrl Abstract / FREE Full Text 22. ↵ Kim EY , Anderson M , Wilson C , Hagmann H , Benzing T , Dryer SE . NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex . Am J Physiol Cell Physiol 305 : C960 – C971 , 2013 . OpenUrl Abstract / FREE Full Text 23. ↵ Kim EY , Choi KJ , Dryer SE . Nephrin binds to the COOH terminus of a large-conductance Ca 2+ -activated K + channel isoform and regulates its expression on the cell surface . Am J Physiol Renal Physiol 295 : F235 – F246 , 2008 . OpenUrl Abstract / FREE Full Text 24. ↵ Kim EY , Dryer SE . Effects of insulin and high glucose on mobilization of slo1 BK Ca channels in podocytes . J Cell Physiol 226 : 2307 – 2315 , 2011 . OpenUrl CrossRef Medline 25. ↵ Kishore B , Nelson R , Miller RL , Carlson N , Kohan D . P2Y 2 receptors and water transport in the kidney . Purinergic Signal 5 : 491 – 499 , 2009 . OpenUrl CrossRef Medline Web of Science 26. ↵ Komlosi P , Bell PD , Zhang ZR . Tubuloglomerular feedback mechanisms in nephron segments beyond the macula densa . Curr Opin Nephrol Hypertens 18 : 57 – 62 , 2009 . OpenUrl CrossRef Medline Web of Science 27. ↵ Kraft R , Grimm C , Frenzel H , Harteneck C . Inhibition of TRPM2 cation channels by N -( p -amylcinnamoyl)anthranilic acid . Br J Pharmacol 148 : 264 – 273 , 2006 . OpenUrl CrossRef Medline Web of Science 28. ↵ Krall P , Canales CP , Kairath P , Carmona-Mora P , Molina J , Carpio JD , Ruiz P , Mezzano SA , Li J , Wei C , Reiser J , Young JI , Walz K . Podocyte-specific overexpression of wild type or mutant Trpc6 in mice is sufficient to cause glomerular disease . PLos One 5 : e12859 , 2010 . OpenUrl CrossRef Medline 29. ↵ Kriz W , Shirato I , Nagata M , LeHir M , Lemley KV . The podocyte's response to stress: the enigma of foot process effacement . Am J Physiol Renal Physiol 304 : F333 – F347 , 2013 . OpenUrl Abstract / FREE Full Text 30. ↵ Lehrmann H , Thomas J , Kim SJ , Jacobi C , Leipziger J . Luminal P2Y 2 receptor-mediated inhibition of Na + absorption in isolated perfused mouse CCD . J Am Soc Nephrol 13 : 10 – 18 , 2002 . OpenUrl Abstract / FREE Full Text 31. ↵ Li A , Banerjee J , Leung CT , Peterson-Yantorno K , Stamer WD , Civan MM . Mechanisms of ATP release, the enabling step in purinergic dynamics . Int J Exp Cell Physiol Biochem Pharmacol 28 : 1135 – 1144 , 2011 . OpenUrl CrossRef 32. ↵ Möller CC , Wei C , Altintas MM , Li J , Greka A , Ohse T , Pippin JW , Rastaldi MP , Wawersik S , Schiavi S , Henger A , Kretzler M , Shankland SJ , Reiser J . Induction of TRPC6 channel in acquired forms of proteinuric kidney disease . J Am Soc Nephrol 18 : 29 – 36 , 2007 . OpenUrl Abstract / FREE Full Text 33. ↵ Pavenstädt H , Kriz W , Kretzler M . Cell biology of the glomerular podocyte . Physiol Rev 83 : 253 – 307 , 2003 . OpenUrl Abstract / FREE Full Text 34. ↵ Peti-Peterdi J . Calcium wave of tubuloglomerular feedback . Am J Physiol Renal Physiol 291 : F473 – F480 , 2006 . OpenUrl Abstract / FREE Full Text 35. ↵ Peti-Peterdi J , Sipos A . A high-powered view of the filtration barrier . J Am Soc Nephrol 21 : 1835 – 1841 , 2010 . OpenUrl Abstract / FREE Full Text 36. ↵ Pochynyuk O , Bugaj V , Rieg T , Insel PA , Mironova E , Vallon V , Stockand JD . Paracrine regulation of the epithelial Na + channel in the mammalian collecting duct by purinergic P2Y 2 receptor tone . J Biol Chem 283 : 36599 – 36607 , 2008 . OpenUrl Abstract / FREE Full Text 37. ↵ Pochynyuk O , Rieg T , Bugaj V , Schroth J , Fridman A , Boss GR , Insel PA , Stockand JD , Vallon V . Dietary Na + inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y 2 -receptor tone . FASEB J 24 : 2056 – 2065 , 2010 . OpenUrl Abstract / FREE Full Text 38. ↵ Potthoff SA , Stegbauer J , Becker J , Wagenhaeuser PJ , Duvnjak B , Rump LC , Vonend O . P2Y 2 receptor deficiency aggravates chronic kidney disease progression . Front Physiol 4 : 2013 . 39. ↵ Praetorius HA , Leipziger J . Intrarenal purinergic signaling in the control of renal tubular transport . Ann Rev Physiol 72 : 377 – 393 , 2010 . OpenUrl CrossRef Medline Web of Science 40. ↵ Reiser J , Polu KR , Moller CC , Kenlan P , Altintas MM , Wei C , Faul C , Herbert S , Villegas I , Avila-Casado C , McGee M , Sugimoto H , Brown D , Kalluri R , Mundel P , Smith PL , Clapham DE , Pollak MR . TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function . Nat Gen 37 : 739 – 744 , 2005 . OpenUrl CrossRef Medline Web of Science 41. ↵ Ren Y , D'Ambrosio MA , Garvin JL , Wang H , Carretero OA . Possible mediators of connecting tubule glomerular feedback . Hypertension 53 : 319 – 323 , 2009 . OpenUrl CrossRef 42. ↵ Ren Y , Garvin JL , Liu R , Carretero OA . Possible mechanism of efferent arteriole (Ef-Art) tubuloglomerular feedback . Kidney Int 71 : 861 – 866 , 2007 . OpenUrl CrossRef Medline Web of Science 43. ↵ Rieg T , Bundey RA , Chen Y , Deschenes G , Junger W , Insel PA , Vallon V . Mice lacking P2Y 2 receptors have salt-resistant hypertension and facilitated renal Na + and water reabsorption . FASEB J 21 : 3717 – 3726 , 2007 . OpenUrl Abstract / FREE Full Text 44. ↵ Savin VJ , Terreros DA . Filtration in single isolated mammalian glomeruli . Kidney Int 20 : 188 – 197 , 1981 . OpenUrl CrossRef Medline Web of Science 45. ↵ Schnermann J . Maintained tubuloglomerular feedback responses during acute inhibition of P2 purinergic receptors in mice . Am J Physiol Renal Physiol 300 : F339 – F344 , 2011 . OpenUrl Abstract / FREE Full Text 46. ↵ Schnermann J , Briggs JP . Tubuloglomerular feedback: mechanistic insights from gene-manipulated mice . Kidney Int 74 : 418 – 426 , 2008 . OpenUrl CrossRef Medline Web of Science 47. ↵ Shirley DG , Bailey MA , Unwin RJ . In vivo stimulation of apical P2 receptors in collecting ducts: evidence for inhibition of sodium reabsorption . Am J Physiol Renal Physiol 288 : F1243 – F1248 , 2005 . OpenUrl Abstract / FREE Full Text 48. ↵ Singh P , Thomson SC . Renal homeostasis and tubuloglomerular feedback . Curr Opin Nephrol Hypertens 19 : 59 – 64 , 2010 . OpenUrl CrossRef Medline Web of Science 49. ↵ Tian D , Jacobo SM , Billing D , Rozkalne A , Gage SD , Anagnostou T , Pavenstädt H , Hsu HH , Schlöndorff J , Ramos A , Greka A . Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels . Science Sig 3 : ra77 , 2010 . OpenUrl 50. ↵ Toma I , Bansal E , Meer EJ , Kang JJ , Vargas SL , Peti-Peterdi J . Connexin 40 and ATP-dependent intercellular calcium wave in renal glomerular endothelial cells . Am J Physiol Regul Integr Comp Physiol 294 : R1769 – R1776 , 2008 . OpenUrl Abstract / FREE Full Text 51. ↵ Vallon V , Rieg T . Regulation of renal NaCl and water transport by the ATP/UTP/P2Y 2 receptor system . Am J Physiol Renal Physiol 301 : F463 – F475 , 2011 . OpenUrl Abstract / FREE Full Text 52. ↵ von Kügelgen I , Wetter A . Molecular pharmacology of P2Y-receptors . N S Arch Pharmacol 362 : 310 – 323 , 2000 . OpenUrl CrossRef Medline Web of Science 53. ↵ Vonend O , Stegbauer J , Sojka J , Habbel S , Quack I , Robaye B , Boeynaems JM , Rump LC . Noradrenaline and extracellular nucleotide cotransmission involves activation of vasoconstrictive P2X(1,3)- and P2Y6-like receptors in mouse perfused kidney . Br J Pharmacol 145 : 66 – 74 , 2005 . OpenUrl CrossRef Medline Web of Science 54. ↵ Wang Z , Wei X , Zhang Y , Ma X , Li B , Zhang S , Du P , Zhang X , Yi F . NADPH oxidase-derived ROS contributes to upregulation of TRPC6 expression in puromycin aminonucleoside-induced podocyte injury . Cell Physiol Biochem 24 : 619 – 626 , 2009 . OpenUrl CrossRef Medline Web of Science 55. ↵ Winn MP , Conlon PJ , Lynn KL , Farrington MK , Creazzo T , Hawkins AF , Daskalakis N , Kwan SY , Ebersviller S , Burchette JL , Pericak-Vance MA , Howell DN , Vance JM , Rosenberg PB . A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis . Science 308 : 1801 – 1804 , 2005 . OpenUrl Abstract / FREE Full Text Previous Next Back to top About the Cover About the Cover Cover image Image 1: Xin Zhang, Zi-Lun Li, John R Woollard, Alfonso Eirin, Behzad Ebrahimi, John A Crane, Xiang- Yang Zhu, Aditya Pawar, James D Krier, Kyra L. Jordan, Hui Tang, Stephen C. Textor, Amir Lerman, and Lilach O. Lerman. Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00043.2013. Image 2: Yun-Hee Choi, Brian T. McNally, and Peter Igarashi. 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ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species

AJP - Renal Physiology , Volume 306 (9): F1088 – May 1, 2014

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References (55)

Publisher
The American Physiological Society
Copyright
Copyright © 2014 the American Physiological Society
ISSN
0363-6127
eISSN
1522-1466
DOI
10.1152/ajprenal.00661.2013
pmid
24553432
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See Article on Publisher Site

Abstract

REFERENCES 1. ↵ Anderson M , Kim EY , Hagmann H , Benzing T , Dryer SE . Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol . Am J Physiol Cell Physiol 305 : C276 – C289 , 2013 . OpenUrl Abstract / FREE Full Text 2. ↵ Anderson M , Roshanravan H , Khine J , Dryer SE . Angiotensin II activation of canonical transient receptor potential-6 (TRPC6) channels in rat podocytes requires generation of reactive oxygen species . J Cell Physiol 229 : 434 – 442 , 2014 . OpenUrl CrossRef Medline 3. ↵ Bailey MA , Turner CM , Hus-Citharel A , Marchetti J , Imbert-Teboul M , Milner P , Burnstock G , Unwin RJ . P 2 Y receptors present in the native and isolated rat glomerulus . Nephron Physiol 96 : 79 – 90 , 2004 . OpenUrl CrossRef 4. ↵ Boute N , Gribouval O , Roselli S , Benessy F , Lee H , Fuchshuber A , Dahan K , Gubler MC , Niaudet P , Antignac C . NPHS2 , encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome . Nat Gen 24 : 349 – 354 , 2000 . OpenUrl CrossRef Medline Web of Science 5. ↵ Dale N . Dynamic ATP signalling and neural development . J Physiol 586 : 2429 – 2436 , 2008 . OpenUrl Abstract / FREE Full Text 6. ↵ Flockerzi V , Nilius B Dietrich A , Gudermann T . TRPC6 . In: Transient Receptor Potential (TRP) Channels , edited by Flockerzi V , Nilius B . Springer Berlin Heidelberg , 2007 , p. 125 – 141 . 7. ↵ Dryer SE , Reiser J . TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology . Am J Physiol Renal Physiol 299 : F689 – F701 , 2010 . OpenUrl Abstract / FREE Full Text 8. ↵ Eckstein F , Cassel D , Levkovitz H , Lowe M , Selinger Z . Guanosine-O(2-thiodiphosphate): An inhibitor of adenylate cyclase stimulation by guanine nucleotides and fluoride ions . J Biol Chem 254 : 9829 – 9834 , 1979 . OpenUrl FREE Full Text 9. ↵ El-Tayeb A , Qi A , Nicholas RA , Müller CE . Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y 2 , P2Y 4 , and P2Y 6 receptors . J Med Chem 54 : 2878 – 2890 , 2011 . OpenUrl CrossRef Medline 10. ↵ Fischer KG , Saueressig U , Jacobshagen C , Wichelmann A , Pavenstadt H . Extracellular nucleotides regulate cellular functions of podocytes in culture . Am J Physiol Renal Physiol 281 : F1075 – F1081 , 2001 . OpenUrl Abstract / FREE Full Text 11. ↵ Heeringa SF , Möller CC , Du J , Yue L , Hinkes B , Chernin G , Vlangos CN , Hoyer PF , Reiser J , Hildebrandt F . A novel TRPC6 mutation that causes childhood FSGS . PLos One 4 : e7771 , 2009 . OpenUrl CrossRef Medline 12. ↵ Hofmann T , Obukhov AG , Schaefer M , Harteneck C , Gudermann T , Schultz G . Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol . Nature 397 : 259 – 263 , 1999 . OpenUrl CrossRef Medline Web of Science 13. ↵ Höhne M , Ising C , Hagmann H , Völker LA , Brähler S , Schermer B , Brinkkoetter PT , Benzing T . Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions . Am J Pathol 182 : 332 – 338 , 2013 . OpenUrl CrossRef Medline Web of Science 14. ↵ Holstein-Rathlou NH . Oscillations and chaos in renal blood flow control . J Am Soc Nephrol 4 : 1275 – 1287 , 1993 . OpenUrl Abstract 15. ↵ Holstein-Rathlou NH , Wagner AJ , Marsh DJ . Tubuloglomerular feedback dynamics and renal blood flow autoregulation in rats . Am J Physiol Renal Fluid Electrolyte Physiol 260 : F53 – F68 , 1991 . OpenUrl Abstract / FREE Full Text 16. ↵ Homolya L , Watt WC , Lazarowski ER , Koller BH , Boucher RC . Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y 2 receptor (−/−) mice . J Biol Chem 274 : 26454 – 26460 , 1999 . OpenUrl Abstract / FREE Full Text 17. ↵ Huber TB , Schermer B , Müller RU , Höhne M , Bartram M , Calixto A , Hagmann H , Reinhardt C , Koos F , Kunzelmann K , Shirokova E , Krautwurst D , Harteneck C , Simons M , Pavenstädt H , Kerjaschki D , Thiele C , Walz G , Chalfie M , Benzing T . Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels . Proc Natl Acad Sci USA 103 : 17079 – 17086 , 2006 . OpenUrl Abstract / FREE Full Text 18. ↵ Ilatovskaya DV , Palygin O , Levchenko V , Staruschenko A . Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli . Am J Physiol Cell Physiol 305 : C1050 – C1059 , 2013 . OpenUrl Abstract / FREE Full Text 19. ↵ Jung S , Mühle A , Schaefer M , Strotmann R , Schultz G , Plant TD . Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth . J Biol Chem 278 : 3562 – 3571 , 2003 . OpenUrl Abstract / FREE Full Text 20. ↵ Kim EY , Anderson M , Dryer SE . Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species . Am J Physiol Renal Physiol 302 : F298 – F307 , 2012 . OpenUrl Abstract / FREE Full Text 21. ↵ Kim EY , Anderson M , Dryer SE . Sustained activation of N -methyl- d -aspartate receptors in podoctyes leads to oxidative stress, mobilization of transient receptor potential canonical 6 channels, nuclear factor of activated T cells activation, and apoptotic cell death . Mol Pharmacol 82 : 728 – 737 , 2012 . OpenUrl Abstract / FREE Full Text 22. ↵ Kim EY , Anderson M , Wilson C , Hagmann H , Benzing T , Dryer SE . NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex . Am J Physiol Cell Physiol 305 : C960 – C971 , 2013 . OpenUrl Abstract / FREE Full Text 23. ↵ Kim EY , Choi KJ , Dryer SE . Nephrin binds to the COOH terminus of a large-conductance Ca 2+ -activated K + channel isoform and regulates its expression on the cell surface . Am J Physiol Renal Physiol 295 : F235 – F246 , 2008 . OpenUrl Abstract / FREE Full Text 24. ↵ Kim EY , Dryer SE . Effects of insulin and high glucose on mobilization of slo1 BK Ca channels in podocytes . J Cell Physiol 226 : 2307 – 2315 , 2011 . OpenUrl CrossRef Medline 25. ↵ Kishore B , Nelson R , Miller RL , Carlson N , Kohan D . P2Y 2 receptors and water transport in the kidney . Purinergic Signal 5 : 491 – 499 , 2009 . OpenUrl CrossRef Medline Web of Science 26. ↵ Komlosi P , Bell PD , Zhang ZR . Tubuloglomerular feedback mechanisms in nephron segments beyond the macula densa . Curr Opin Nephrol Hypertens 18 : 57 – 62 , 2009 . OpenUrl CrossRef Medline Web of Science 27. ↵ Kraft R , Grimm C , Frenzel H , Harteneck C . Inhibition of TRPM2 cation channels by N -( p -amylcinnamoyl)anthranilic acid . Br J Pharmacol 148 : 264 – 273 , 2006 . OpenUrl CrossRef Medline Web of Science 28. ↵ Krall P , Canales CP , Kairath P , Carmona-Mora P , Molina J , Carpio JD , Ruiz P , Mezzano SA , Li J , Wei C , Reiser J , Young JI , Walz K . Podocyte-specific overexpression of wild type or mutant Trpc6 in mice is sufficient to cause glomerular disease . PLos One 5 : e12859 , 2010 . OpenUrl CrossRef Medline 29. ↵ Kriz W , Shirato I , Nagata M , LeHir M , Lemley KV . The podocyte's response to stress: the enigma of foot process effacement . Am J Physiol Renal Physiol 304 : F333 – F347 , 2013 . OpenUrl Abstract / FREE Full Text 30. ↵ Lehrmann H , Thomas J , Kim SJ , Jacobi C , Leipziger J . Luminal P2Y 2 receptor-mediated inhibition of Na + absorption in isolated perfused mouse CCD . J Am Soc Nephrol 13 : 10 – 18 , 2002 . OpenUrl Abstract / FREE Full Text 31. ↵ Li A , Banerjee J , Leung CT , Peterson-Yantorno K , Stamer WD , Civan MM . Mechanisms of ATP release, the enabling step in purinergic dynamics . Int J Exp Cell Physiol Biochem Pharmacol 28 : 1135 – 1144 , 2011 . OpenUrl CrossRef 32. ↵ Möller CC , Wei C , Altintas MM , Li J , Greka A , Ohse T , Pippin JW , Rastaldi MP , Wawersik S , Schiavi S , Henger A , Kretzler M , Shankland SJ , Reiser J . Induction of TRPC6 channel in acquired forms of proteinuric kidney disease . J Am Soc Nephrol 18 : 29 – 36 , 2007 . OpenUrl Abstract / FREE Full Text 33. ↵ Pavenstädt H , Kriz W , Kretzler M . Cell biology of the glomerular podocyte . Physiol Rev 83 : 253 – 307 , 2003 . OpenUrl Abstract / FREE Full Text 34. ↵ Peti-Peterdi J . Calcium wave of tubuloglomerular feedback . Am J Physiol Renal Physiol 291 : F473 – F480 , 2006 . OpenUrl Abstract / FREE Full Text 35. ↵ Peti-Peterdi J , Sipos A . A high-powered view of the filtration barrier . J Am Soc Nephrol 21 : 1835 – 1841 , 2010 . OpenUrl Abstract / FREE Full Text 36. ↵ Pochynyuk O , Bugaj V , Rieg T , Insel PA , Mironova E , Vallon V , Stockand JD . 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A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis . Science 308 : 1801 – 1804 , 2005 . OpenUrl Abstract / FREE Full Text Previous Next Back to top About the Cover About the Cover Cover image Image 1: Xin Zhang, Zi-Lun Li, John R Woollard, Alfonso Eirin, Behzad Ebrahimi, John A Crane, Xiang- Yang Zhu, Aditya Pawar, James D Krier, Kyra L. Jordan, Hui Tang, Stephen C. Textor, Amir Lerman, and Lilach O. Lerman. Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00043.2013. Image 2: Yun-Hee Choi, Brian T. McNally, and Peter Igarashi. Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1β . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00582.2012. Image 3: Soundarapandian Vijayakumar, Hu Peng, and George J Schwartz. Galectin-3 mediates oligomerization of secreted hensin using its carbohydrate recognition domain . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00498.2012. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords podocyte glomerular filtration TRPC6 Purinergic podocin NADPH oxidase Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Renal Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Dryer American Journal of Physiology - Renal Physiology May 2014, 306 (9) F1088-F1097; DOI: 10.1152/ajprenal.00661.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria LIM homeobox transcription factor 1B expression affects renal interstitial fibrosis and apoptosis in unilateral ureteral obstructed rats Show more Articles Related Articles No related articles found. Web of Science Scopus PubMed Google Scholar Cited By... 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