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- Publisher
- The American Physiological Society
- Copyright
- Copyright © 2012 the American Physiological Society
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- DOI
- 10.1152/japplphysiol.01023.2011
- pmid
- 22207722
- Publisher site
- See Article on Publisher Site
Abstract
Assessment of locomotion following exposure of animals to noxious or painful stimuli can offer significant insights into underlying mechanisms of injury and the effectiveness of various treatments. We developed a novel method to track the movement of mice in two dimensions using computer vision and neural network algorithms. By using this system we demonstrated that mice exposed to chlorine (Cl 2 ) gas developed impaired locomotion and increased immobility for up to 9 h postexposure. Postexposure administration of buprenorphine, a common analgesic agent, increased locomotion and decreased immobility times in Cl 2 - but not air-exposed mice, most likely by decreasing Cl 2 -induced pain. This method can be adapted to assess the effectiveness of various therapies following exposure to a variety of chemical and behavioral noxious stimuli. ethograms buprenorphine pain total distance covered mobility Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print December 2011 , doi: 10.1152/japplphysiol.01023.2011 Journal of Applied Physiology March 2012 vol. 112 no. 6 1064-1072 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: japplphysiol.01023.2011v1 112/6/1064 most recent Classifications Innovative Methodology Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Responses Submit a response No responses published Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Filippidis, A. S. Articles by Matalon, S. PubMed PubMed citation Articles by Filippidis, A. S. Articles by Matalon, S. Related Content Load related web page information Current Issue March 2012, 112 (6) Alert me to new issues of Journal of Applied Physiology About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 8750-7587 Online ISSN: 1522-1601 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); } catch(err) {}
Journal
Journal of Applied Physiology – The American Physiological Society
Published: Mar 15, 2012