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ROBERT YANKOVICH of Minnesota Medical School, Minneapolis, Minnesota 554% WANGENSTEEN,DOUGLAS,ROBERTYANKOVICH. Alueolar epithelium transport of albumin sucrose: concentration difference effect. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 47(4): 846-850, 1979.-Isolated Ringer-perfused rabbit lungs were used to study albumin sucrose transport across the blood-gas barrier. Lungs were filled to about 20% total lung capacity (TLC) with Ringer solution containing radioactive albumin sucrose, their rate of appearance in the recirculating perfusate was monitored. From this the product permeability x area (PA) was calculated. In the middle of the MO-min experiments, some alveolar fluid was removed. In control experiments, the same fluid was reinstilled, in other experiments new fluid with higher test molecule concentrations was infused. In all experiments the results for both molecules were similar: PA for the second half of the experiment was 80% of that in the first half. The reduction was probably due to a decrease in exchange area. We thus find the albumin sucrose permeabilities to be proportional to their concentration difference. In addition, the PA for sucrose was roughly four times that of albumin. These results can possibly be explained by a two-compartment model with two parallel pathways across the alveolar epithelium. One pathway would be
Journal of Applied Physiology – The American Physiological Society
Published: Oct 1, 1979
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