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Altered expression of sodium pump isoforms in the inflamed intestine of Trichinella spiralis-infected rats

Altered expression of sodium pump isoforms in the inflamed intestine of Trichinella... AND STEPHEN M. COLLINS University Medical Centre, Diseases Research Unit, McMaster Ontario L&N 325, Canada and biochemical studies have revealed three isoforms (aI, CQ,and (Ye)of the catalytic subunit (15, 38) and two isoforms (& and &) of the regulatory subunit (29, 45). These isoforms exhibit tissue-specific expression and are developmentally regulated (29, 33). The dominant a-isoform in most smooth muscle is cyl (37, 45); the cy2isoform is expressed to a lesser degree (16), cy3isoform is usually undetectable in a variety of muscle (40). Moreover, the aI-isoform generally has a greater affinity for Na+ than the cy2- and cu3-isoforms (19). Recently, Burke et al. (6) found that the expression of the cyl-subunit in canine colonic circular muscle correlated well with electrical properties of the tissue. In previous studies, we have reported a ~80% decrease in the K+-stimulated and ouabain-sensitive activity of p-nitrophenylphosphatase (Na+ marker) and a >90% decrease in the ouabain-sensitive uptake of 86Rb by muscle from TrichineZLa spiral&infected rats (30). Inhibition of activity by vanadate was accompanied by an increase in isometric tension induced by carbachol in muscle from control rats. This phenomenon was absent in muscle from infected rats suggesting that T. spiralis induced suppression of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Altered expression of sodium pump isoforms in the inflamed intestine of Trichinella spiralis-infected rats

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Publisher
The American Physiological Society
Copyright
Copyright © 1993 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
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Abstract

AND STEPHEN M. COLLINS University Medical Centre, Diseases Research Unit, McMaster Ontario L&N 325, Canada and biochemical studies have revealed three isoforms (aI, CQ,and (Ye)of the catalytic subunit (15, 38) and two isoforms (& and &) of the regulatory subunit (29, 45). These isoforms exhibit tissue-specific expression and are developmentally regulated (29, 33). The dominant a-isoform in most smooth muscle is cyl (37, 45); the cy2isoform is expressed to a lesser degree (16), cy3isoform is usually undetectable in a variety of muscle (40). Moreover, the aI-isoform generally has a greater affinity for Na+ than the cy2- and cu3-isoforms (19). Recently, Burke et al. (6) found that the expression of the cyl-subunit in canine colonic circular muscle correlated well with electrical properties of the tissue. In previous studies, we have reported a ~80% decrease in the K+-stimulated and ouabain-sensitive activity of p-nitrophenylphosphatase (Na+ marker) and a >90% decrease in the ouabain-sensitive uptake of 86Rb by muscle from TrichineZLa spiral&infected rats (30). Inhibition of activity by vanadate was accompanied by an increase in isometric tension induced by carbachol in muscle from control rats. This phenomenon was absent in muscle from infected rats suggesting that T. spiralis induced suppression of the

Journal

AJP - Gastrointestinal and Liver Physiology – The American Physiological Society

Published: Jun 1, 1993

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