ISCHEMIC TISSUE occur duringrespiratory failure, systemic hypotension, and regional hypoperfusion of organs. One of the main biologic events occurring immediately after tissue ischemia is the decrease in ular ATP levels (6, 20). If the adverse conditions persist, a cascade of biologic events occurs within the that lead to irreversible and eventually death. To understand the tissue produced by ischemia, many hypotheses have been considered to explain ular subsequent to ATP depletion. For example, the elevation of cytosolic Ca2+ is a wellrecognized feature of myocardial ischemic . The removal of extraular Ca2+ was found to protect cultured hepatocytes against toxicity caused by a number of toxic chemicals. Because elevated Ca2+ disturbs a myriad of tightly regulated Ca2+-dependent metabolic reactions, the influx of extraular Ca2+ has been proposed to be the culprit responsible for the irreversible damage (6, 26). Another frequently observed feature of tissue ischemic is the decrease in intraular pH. Acidosis occurring in cardiac muscle during hypoxia was claimed to promote functional recovery upon reation (2). Low pH was observed to protect hepatocytes, renal tubular epithelial s, and heart against from anoxia and substrate 0363-6143/96 $5.00 Copyright o deprivation (9, 12). A hypothesis of a âpH paradoxâ was
AJP - Cell Physiology – The American Physiological Society
Published: Jan 1, 1996
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