Adrenergic blockade prevents endotoxin-induced increases in glucose metabolism

Adrenergic blockade prevents endotoxin-induced increases in glucose metabolism Center, New Orleans, Louisiana iol. 255 (Endocrinol. Metab. 18): E629-E635,1988.-Combined cy-and @adrenergicblockade was usedto investigate the role of in -induced elevations in glucose . Glucose were measuredbefore and for 4 h the injection of El00 pg/lOO g body wt iv, 30% lethal dose (LD& at 24 h]. Adrenergic blockade was achieved by the bolusinjection of phentolamine andpropranolol followed by their continuous infusion. -treated rats exhibited a transient hyperglycemia and sustained (>4 h) increase in plasmalactate concentration, as well as elevated rates of glucoseappearance(R8)83%), disappearance(&, 58%), recycling (160%), and metabolic clearance (23%). Adrenergic blockade vented -induced increasesin plasmaglucoseconcentration, K, &, and recycling but not glucose clearance.The increasein plasmalactate concentration was blunted by 35%. 2 h, endotoxic animals infused with adrenergic antagonists developedhypoglycemia, which may have resulted from an increasedplasmainsulin concentration. The attenuation of elevated glucoseturnover by adrenergic blockade in the -treated animals was not due to a reduction in plasma glucagonlevel or differences in plasma insulin concentration. Administration of the cy-or /3-adrenergic antagonistsseparately blunted but did not vent -induced changes in glucose, and therefore the efficacy of the adrenergic blockadecould not be assigned a singlereceptor class.These to resultsindicate that important contributory are factors to many of the early alterations http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Adrenergic blockade prevents endotoxin-induced increases in glucose metabolism

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Publisher
The American Physiological Society
Copyright
Copyright © 1988 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
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Abstract

Center, New Orleans, Louisiana iol. 255 (Endocrinol. Metab. 18): E629-E635,1988.-Combined cy-and @adrenergicblockade was usedto investigate the role of in -induced elevations in glucose . Glucose were measuredbefore and for 4 h the injection of El00 pg/lOO g body wt iv, 30% lethal dose (LD& at 24 h]. Adrenergic blockade was achieved by the bolusinjection of phentolamine andpropranolol followed by their continuous infusion. -treated rats exhibited a transient hyperglycemia and sustained (>4 h) increase in plasmalactate concentration, as well as elevated rates of glucoseappearance(R8)83%), disappearance(&, 58%), recycling (160%), and metabolic clearance (23%). Adrenergic blockade vented -induced increasesin plasmaglucoseconcentration, K, &, and recycling but not glucose clearance.The increasein plasmalactate concentration was blunted by 35%. 2 h, endotoxic animals infused with adrenergic antagonists developedhypoglycemia, which may have resulted from an increasedplasmainsulin concentration. The attenuation of elevated glucoseturnover by adrenergic blockade in the -treated animals was not due to a reduction in plasma glucagonlevel or differences in plasma insulin concentration. Administration of the cy-or /3-adrenergic antagonistsseparately blunted but did not vent -induced changes in glucose, and therefore the efficacy of the adrenergic blockadecould not be assigned a singlereceptor class.These to resultsindicate that important contributory are factors to many of the early alterations

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Nov 1, 1988

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