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Adenosine A1 receptors, KATP channels, and ischemic preconditioning in dogs

tioning in dogs is blocked by the KATP channel antagonists glibenclamide (11) sodium 5-hydroxydecanoate (2). Thus the current study was designed to test the hypothesis that adenosine mediates in the canine heart by activating KATP channels. Accordingly, our first objective was to characterize the role of adenosine the receptor subtype involved in ischemic in dogs, since previous studies that implicate this nucleoside were primarily performed in rabbits. Our second objective was to determine whether the anti-ischemic effects of exogenously administered adenosine are a result of KATP channel opening by pretreating animals with the KATI> channel antagonist glibenclamide. MATERIALS METHODS General Surgical Preparation All experiments performed in this study conformed to the guidelines of the Animal Care Committee of the Medical College of Wisconsin. The Medical College of Wisconsin is accredited by the American Association of Laboratory Animal Care. Mongrel dogs of either sex, weighing between 20 30 kg, were anesthetized with a combination of intravenous barbital sodium (200 mg/kg) pentobarbital sodium (15 mg/kg) ventilated by a respirator (Harvard Apparatus, South Natick, MA) with room air supplemented with 100% oxygen. Atelectesis was prevented by maintaining an end-expiratory pressure of 5-7 cmH,O with a trap. Arterial blood pH blood gases http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

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