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The purpose of the present study was to examine the effects of an acute dose of the dual dopamine (DA) and norepinephrine (NE) reuptake inhibitor bupropion (Bup) on brain (T brain ), body core (T core ), and tail skin (T tail ) temperature in freely moving rats and to simultaneously monitor the extracellular neurotransmitter concentrations in the preoptic area and anterior hypothalamus (PO/AH). A microdialysis probe was inserted in the PO/AH, and samples for NE, DA, and serotonin (5-HT) were collected every 20 min before and after the injection of 17 mg/kg of Bup, for a total sampling time of 180 min. T core was monitored using a biotelemetry system. T brain and T tail , an index of heat loss response, were also measured. Both NE and DA levels in the PO/AH significantly increased after Bup injection compared with the baseline levels, reaching ∼450 and 230%, respectively, 40 min after injection. There was no effect on 5-HT release. The neurotransmitter changes were accompanied by a significant decrease in T tail and an increase in both T brain and T core compared with the baseline levels. The present results demonstrate that inhibition of NE and DA reuptake suppresses heat loss mechanisms and elevates T brain and T core in freely moving rats. microdialysis; monoamines; preoptic area and anterior hypothalamus; body temperature Address for reprint requests and other correspondence: R. Meeusen, Dept. of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium (e-mail: rmeeusen@vub.ac.be )
Journal of Applied Physiology – The American Physiological Society
Published: Oct 1, 2005
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