Banitt, Peter F., Paul Smits, Stephen B. Williams, Peter Ganz, Mark A. Creager. Activation of ATPsensitive potassium channels contributes to in humans. Am. J. PhysioZ. 271 (Heart Circ. Physiol. 40): H1594-H1598, 1996.-Activation of ATP-sensitive potassium (KATp) channels present on vascular smooth muscle cells causes membrane hyperpolarization vasodilation. The purpose of this study was to determine whether contribute to in humans. Accordingly, we studied the effect of , a KATp channel inhibitor, on hyperemic forearm blood flow. Forearm blood flow was measured by venous occlusion plethysmography. Forearm ischemia was produced by inflating a sphygmomanometric cuff on the arm to suprasystolic pressures for 5 min. After cuff release, forearm blood flow was measured during the hyperemic phase for 5 min. (1 mM blood concentration, n = 6) did not affect basal (2.4 t 0.2 to 2.2 ? 0.1 ml.100 mlll*minl) or peak hyperemic forearm blood flow (21.9 ? 3.8 to 22.6 2 2.9 ml 100 ml-l emin, each P = NS), but it significantly attenuated total hyperemic volume (12.6 t 1.7 vs. 9.2 t 1.8 ml/100 ml, P < 0.02). Vehicle (n = 6) did not affect basal flow, peak hyperemic flow, or total . To determine whether adenosine or
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Oct 1, 1996
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