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ACETYLCHOLINE AND PROSTIGMINE ELECTROPHORESIS AT VISUAL CORTEX NEURONS

ACETYLCHOLINE AND PROSTIGMINE ELECTROPHORESIS AT VISUAL CORTEX NEURONS Neurophysiologie (Received for 2 der Universitaet publicion June Freiburg 20, 1962) im Breisgau, Germany EXPLORION OF CHEMICAL EVENTS neuronal synapses and membranes has been grely advanced by Curtis and Eccles’ technique of recording from single and simultaneous electrophoretic applicion of drugs to these through various barrels of a composite micropipette. Since this method has been applied only to lower structures of the central nervous system of the ca t (spinal cord (1, 3) and brain stem (2)), it seemed of sufficient interest to explore the ac tion of drugs on of the visual , whose various responses to light stimulion have been well studied (6). Some earlier experiments (5) had suggested th of the visual could be actived by local applicion of acetylcholine. Systemic investigion proved th these were highly sensitive to the electric current used for electrophoresis. To distinguish between the pharmacologic effect of the various drug ions and their electrical action, NaCl currents were applied in each case for control. The present study describes the results of iontophoresis of acetylcholine, prostigmine, and dihydro-P-erythroidine, in comparison with the response to NaCl currents, delivered through multibarreled micropipettes to of the visual . These results were briefly outlined in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

ACETYLCHOLINE AND PROSTIGMINE ELECTROPHORESIS AT VISUAL CORTEX NEURONS

Journal of Neurophysiology , Volume 26: 127 – Jan 1, 1963

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Publisher
The American Physiological Society
Copyright
Copyright © 1963 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
See Article on Publisher Site

Abstract

Neurophysiologie (Received for 2 der Universitaet publicion June Freiburg 20, 1962) im Breisgau, Germany EXPLORION OF CHEMICAL EVENTS neuronal synapses and membranes has been grely advanced by Curtis and Eccles’ technique of recording from single and simultaneous electrophoretic applicion of drugs to these through various barrels of a composite micropipette. Since this method has been applied only to lower structures of the central nervous system of the ca t (spinal cord (1, 3) and brain stem (2)), it seemed of sufficient interest to explore the ac tion of drugs on of the visual , whose various responses to light stimulion have been well studied (6). Some earlier experiments (5) had suggested th of the visual could be actived by local applicion of acetylcholine. Systemic investigion proved th these were highly sensitive to the electric current used for electrophoresis. To distinguish between the pharmacologic effect of the various drug ions and their electrical action, NaCl currents were applied in each case for control. The present study describes the results of iontophoresis of acetylcholine, prostigmine, and dihydro-P-erythroidine, in comparison with the response to NaCl currents, delivered through multibarreled micropipettes to of the visual . These results were briefly outlined in

Journal

Journal of NeurophysiologyThe American Physiological Society

Published: Jan 1, 1963

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