Clinical Research Center, Abdominal surgery induces an inflammatory response associated with tissue repair and represents a stressful experiment for involved animals. Because peripheral IL-lp production has been shown to be increased during infection, inflammatory response, and stress (21,26), the aim of our study was to determine 1) the of IL-lp in the abdominal surgery-induced inhibition of emptying and 2) the neural pathways involved in this inhibitory response. MATERIAL Animals Male Sprague-Dawley rats weighing 200-250 g (Charles River, Ville St. Laurent, Canada) were maintained on rat Purina chow and tap water ad libitum. They were housed under conditions of controlled temperature (20 t lÂ°C) and illumination (light on from 6 A.M. to 6 P.M.). Experiments were performed on animals deprived of food for 18 h but allowed free access to water up to the beginning of the experiments. Drugs The following substances were used: recombinant human IL-lp was generously provided by Dr. Nigel Staite from Upjohn Laboratory (Kalamazoo, MI), and IL-lp receptor antagonist (IL-lpra) was a gift from Dr. Jim Vannice of Synergen (Boulder, CO). The peptides were dissolved in saline with 0.1% serum albumin and stored at -70Â°C. These drugs were injected through the jugular vein. Capsaicin (Sigma
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Mar 1, 1996
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